Aims: The purpose of this study was to investigate the effects of glucosamine (GlcN) on hydrogen peroxide (H[sub]2O[sub]2)-induced premature senescence
in human retinal pigment epithelial (RPE) cells in vitro.
--The declining function of the immune system, called immune senescence
, is one of the biggest risk factors for many diseases that occur in advancing age.
Our unifying hypothesis is that stem-cell quiescence maintenance, which requires active proteostasis (protein homeostasis), lies at the basis of stemness, and that its substitution by a senescence
state in aging impairs regeneration.
As we age, our MuSCs transition to a permanently inactive state called senescence
, from which they can't be 'woken up' to form new muscle fibers," said Lorenzo Puri of Sanford Burnham Prebys Medical Discovery Institute (SBP).
in an organism's life is a phase of developmental decline, and a loss of replicative capacity in cell culture.
Removal of early fruiting branches with optimum nitrogen dose caused more source and less sink at early stages leading to delay in onset and progression of senescence
Background: Amyloid [sz] (A[sz]) has been established as a key factor for the pathological changes in the brains of patients with Alzheimer's disease (AD), and cellular senescence
is closely associated with aging and cognitive impairment.
Together with immunological factors, cellular senescence
and the senescence
-associated secretory phenotype (SASP) are currently held to be the largest contributors to inflammaging ; however, a key role of senescence
in patients with the most common ARDs (e.
A buildup of the protein GATA4 forces cells to enter a permanently static state known as senescence
, researchers report in the Sept.
The delay of senescence
was also identified as a major factor to increase the average weight of grains of durum wheat mutants, as a result of extending the ability of producing photoassimilates towards the end of maturation (SPANO et al.
is believed to be responsible for some of the telltale signs of aging, such as weakened bones, less-resilient skin, and slowdowns in organ function.
Fibroblasts are a well-established in vitro model for cellular senescence
(Fulcher et al.