The present results and those of another recent study utilizing a different AAV9 variant and transgene indicate that systemic and sensory neuron
toxicity may be general properties of intravenous delivery of AAV vectors at high doses irrespective of the capsid serotype or transgene.
They identified a signaling pathway known as Wnt that triggers the olfactory stem cell to become a sensory neuron
They discuss structural characterization of EPAC by x-ray crystallography; sensory neuron
cAMP signaling in chronic pain; monitoring real-time cyclic nucleotide dynamics in subcellular microdomains; identifying complexes of adenylyl with A-kinase anchoring proteins; assessing cyclic nucleotide binding domain allostery and dynamics by nuclear magnetic resonance spectroscopy; a protocol for expression and purification of cyclic nucleotide-free protein in E.
To execute this leg extension, a muscle stretch receptor in the extensor muscle, which is stretched in response to the knee tap, sends a signal through a sensory neuron
to the spinal cord.
They cover both neuropathic pain recognized in sensory neuron
disorders and other types of pain less commonly considered, including in Parkinson's disease, amyotrophic lateral sclerosis, and muscle diseases.
The proposed mechanism involves activation of AMPK by metformin, with resultant inhibition of the mTOR (mammalian 'target of rapamycin) pathway leading to reduced sensory neuron
excitability and decreased chronic neuropathic pain (Nat.
by a tendon tap or in the course of daily activities), the muscle spindle is also stretched, generating a faster frequency of action potentials in the sensory neuron
(see Figure 2a).
Neurotrophin 4 (NT-4): Research in mice suggests the absence of this neurotrophic protein may result in sensory neuron
loss as well as deficits in long-term memory.
Neuronal Class Description S1 OLL Head sensory neuron
URY Head sensory neuron
IL2 Head sensory neuron
RIH Ring interneuron ASH Amphids; sensory neuron
RIM Ring motor neuron RIV Ring motor/interneuron CEP Head sensory neuron
AVH Interneuron ADL Amphids; sensory neuron
S2 SMD Ring motor neuron RME Ring motor neuron RMD Ring motor neuron AVB Command interneuron AVA Command interneuron AVE Command interneuron AVD Command interneuron TABLE 6.
Distribution of dihydropyridine and omega-conotoxin-sensitive calcium currents in acutely isolated rat and frog sensory neuron
somata: diameter-dependent L channel expression in frog.
The way the senses work is that a sensory neuron
responds to a "bit" of information about the environment such as red photons, a sound frequency, a pressure differential or a chemical concentration, etc.
We previously demonstrated SSeCKS immunolabeling in primary afferent terminals in lamina II of the rat spinal cord as well as within approximately 40% of small-diameter primary sensory neuron