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Related to sideroblast: Myelodysplastic syndrome, ferritin
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Noun1.sideroblast - an erythroblast having granules of ferritin
erythroblast - a nucleated cell in bone marrow from which red blood cells develop
References in periodicals archive ?
One of the most common causes of secondary acquired sideroblastic anaemia is chronic ethanol consumption, with a ringed sideroblast abnormality occurring in 25-30% of anaemic alcoholic patients (1,4,5).
Telomerase Inhibitor Imetelstat Therapy in Refractory Anemia with Ring Sideroblasts with or without Thrombocytosis.
The anemia of copper deficiency often is associated with the presence of ringed sideroblasts and occurs in a number of clinical settings, including a microcytic, macrocytic, or normocytic anemia.
9]/1 sideroblasts Refractory >5 [less than -- - anaemia (RA) or equal to]1 Refractory >5 [less than -- + anaemia with or equal ringed to]1 sideroblasts (RARS) Refractory 5--20 <5 -- [+ or -] anaemia with excess blasts (RAEB) Chronic [less <5 + [+ or -] myelomonocytic than or leukaemia equal (CMML) to]20 RAEB in 21-- [greater [+ or -] [+ or -] transformation 30 than or (RAEB-T) equal to]5 Bennett, et al.
Patients with mutations in the SF3B1 gene frequently had a specific abnormality of red blood cells in their bone marrow, called ring sideroblasts, researchers said.
The peripheral smear of patients typically includes two distinct erythrocyte populations: normochromic normocytic erythrocytes together with hypochromic microcytic cells Bone marrow examination reveals ringed sideroblasts due to increased iron within mitochondrial ferritin (57).
der(4)t(1;4)(q21;q35) +mar, t(7;13), t(8;21) (q22;q22), t(1;X)(p21;q31),-7 in refractory anaemia with excessive blasts transformation (RAEB-t), del(2)(q33-ter) in chronic myelomonocytic leukemia (CMMOL) and trisomy 14 in refractory anaemia with ring sideroblasts (RARS).
26) (A sideroblastic anemia is marked by large numbers of ringed sideroblasts in the bone marrow, ineffective production of red blood cells, hypochromic erythrocytes in the peripheral blood, and, usually, increased levels of tissue iron.
These subtypes include: refractory anaemia (RA) or refractory anaemia with ringed sideroblasts (RARS) if accompanied by neutropenia or thrombocytopenia or requiring transfusions; refractory anaemia with excess blasts (RAEB), refractory anaemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukaemia (CMMoL).
S Food and Drug Administration (FDA) on May 2, 2006 for the treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British (FAB) subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia), and Intermediate-1, Intermediate-2, and High-Risk International Prognostic Scoring System (IPSS) groups.