has a second critical role, one triggered by emergencies like a break in both DNA strands of a chromosome.
Increasing levels of the mouse sirtuin
, SirT1, prevents mice from developing heart problems and fatty livers even when they are fed high-fat diets, researchers at the University of Cincinnati College of Medicine and the Spanish National Cancer Research Center in Madrid reported June 30 in Proceedings of the National Academy of Sciences.
This represents the first sirtuin
inhibitor to enter clinical trials and validates the work of our drug discovery and design program focused on the sirtuin
family of enzymes, specifically, our selective SIRT1 inhibitor program.
was first discovered to extend life span in yeast (3) and later discovered to extend the life span of nematode worms and fruit flies.
Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries, increases the activity of a specific sirtuin
, SIRT1, that protects the body from diseases by revving up the mitochondria, a kind of cellular battery that slowly runs down as we age.
The authors presented evidence that resveratrol does not directly activate sirtuin
1, a protein associated with aging.
Previous research had shown that making more of a sirtuin
Life-span boosting by sirtuins
is established via a study in which yeast cell's life-span was increased by 30% after an extra copy of sirtuin
gene was added to the cell.
developers of the RapidFire[R] highthroughputmass spectrometry system, and BlueSky Biotech, service provider of discovery biologicals, today announced their collaboration to offer the industry's only Sirtuin
(SIRT, silent mating type information regulation homolog) enzyme preparations fully validated in a label‐free functional assay.
Guarente and others believe that drugs that boost sirtuin
production could help fight diseases of aging such as diabetes and Alzheimer's, improving health in later life and potentially extending lifespan.
Sirtris Pharmaceuticals has established a drug discovery capability to exploit sirtuin
modulation for the treatment of human disease, an approach that has the potential to generate multiple clinically and commercially important products.
Shin-ichiro Imai demonstrated that the protein sirtuin
is required in order for calorie restriction to enhance the activity of orexin.