blocker

(redirected from sodium channel blocker)
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block

 (blŏk)
n.
1.
a. A solid piece of a hard substance, such as wood, having one or more flat sides.
b. Such a piece used as a construction member or as a support.
c. Such a piece upon which chopping or cutting is done: a butcher's block.
d. Such a piece upon which persons are beheaded.
e. One of a set of small wooden or plastic pieces, such as a cube, bar, or cylinder, used as a building toy.
f. Printing A large amount of text.
g. Sports A starting block.
2. A stand from which articles are displayed and sold at an auction: Many priceless antiques went on the block.
3. A mold or form on which an item is shaped or displayed: a hat block.
4. A substance, such as wood or stone, that has been prepared for engraving.
5.
a. A pulley or a system of pulleys set in a casing.
b. An engine block.
6. A bloc.
7. A set of like items, such as shares of stock, sold or handled as a unit.
8. A group of four or more unseparated postage stamps forming a rectangle.
9. Canadian A group of townships in an unsurveyed area.
10.
a. A usually rectangular section of a city or town bounded on each side by consecutive streets.
b. A segment of a street bounded by consecutive cross streets and including its buildings and inhabitants.
11. A large building divided into separate units, such as apartments.
12. A length of railroad track controlled by signals.
13. Something that obstructs; an obstacle: The disabled car formed a block in traffic.
14. The act of preventing someone or something from advancing, passing, or progressing, as:
a. Sports An act of bodily obstruction, as of a player or the ball.
b. Football An act of legally using one's body to obstruct or move a defensive player so that a player in possession of the ball may advance downfield, pass, or otherwise execute an offensive play.
15. Medicine Interruption or obstruction of a physiological function: nerve block.
16. Psychology A sudden cessation of speech or a thought process without an immediate observable cause, sometimes considered a consequence of repression. Also called mental block.
17. Slang The human head: threatened to knock my block off.
v. blocked, block·ing, blocks
v.tr.
1.
a. To stop or impede the passage of or movement through; obstruct: block traffic; mud that blocked the pipe.
b. To prevent from happening, succeeding, or progressing: blocked every attempt to reform the rules.
c. To shut out from view: a curtain blocking the stage.
d. To stop the passage of (a motion or bill) in a legislative assembly.
e. Sports To prevent or slow the movement of (an opponent) by using one's body, as by making a block in football.
f. Sports To stop or deflect (a ball or puck) by using one's body.
g. Medicine To interrupt or obstruct the functioning of (a physiological process), especially by the use of drugs.
h. Psychology To fail to remember.
2. To support, strengthen, or retain in place by means of a block.
3. To shape, mold, or form with or on a block: block a hat.
4. To indicate broadly without great detail; sketch. Often used with out: block out a plan of action; block out stage movements.
5. To run (trains) on a block system.
v.intr.
1. Sports
a. To obstruct the movement of an opponent by using one's body.
b. To stop or deflect a ball or puck by using one's body.
2. To suffer a mental block. Often used with on: I blocked on his name.
Phrasal Verb:
block out
1. To cover over so as to be illegible: block out sensitive information from a document before releasing it.
2. To repress (a traumatic event, for example) from conscious memory.
Idioms:
go on the block
To be offered for sale.
out of the blocks
From a starting position, as in a race or contest: The company has in the past been slow out of the blocks to adapt to consumer tastes.
put on the block
To offer for sale.

[Middle English blok, from Old French bloc, from Middle Dutch.]

block′er n.
Synonyms: block, hide1, obscure, obstruct, screen, shroud
These verbs mean to cut off from sight: a tree that blocked the view; a road hidden by brush; mist that obscured the mountain peak; skyscrapers obstructing the sky; a fence that screens the alley; a face shrouded by a heavy veil.

blocker

(ˈblɒkə)
n
1. a person or thing that acts as a block
2. (Physiology) physiol an agent that blocks a physiological function, such as the transport of an ion across an ion channel

block•er

(ˈblɒk ər)

n.
1. a person or thing that blocks.
2. a substance that inhibits the physiological action of another substance.
[1200–50]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.blocker - a football player whose responsibility is to block players attempting to stop an offensive playblocker - a football player whose responsibility is to block players attempting to stop an offensive play
football player, footballer - an athlete who plays American football
2.blocker - a class of drugs that inhibit (block) some biological processblocker - a class of drugs that inhibit (block) some biological process
alpha blocker, alpha-adrenergic blocker, alpha-adrenergic blocking agent, alpha-blocker - any of various drugs that block alpha-adrenergic receptors; used in treating benign prostatic hyperplasia; relaxes the muscles of the prostate and bladder
beta blocker, beta-adrenergic blocker, beta-adrenergic blocking agent, beta-blocking agent - any of various drugs used in treating hypertension or arrhythmia; decreases force and rate of heart contractions by blocking beta-adrenergic receptors of the autonomic nervous system
labetalol, labetalol hydrochloride, Normodyne, Trandate - antihypertensive drug (trade names Trandate and Normodyne) that blocks alpha and beta-adrenergic receptors of the sympathetic nervous system (leading to a decrease in blood pressure)
medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease
neuromuscular blocking agent - a substance that interferes with the neural transmission between motor neurons and skeletal muscles
Translations

block·er

n. bloqueador;
calcium channel ______ del canal cálcico.

blocker

n bloqueador m, bloqueante m; angiotensin receptor — bloqueador or antagonista m del receptor de angiotensina; beta — beta-bloqueador, beta-bloqueante; calcium channel — bloqueador or bloqueante de los canales del calcio; H2 blocker bloqueador H2; neuromuscular — bloqueador or bloqueante neuromuscular
References in periodicals archive ?
Although this hemodynamic response is due to sympathetic adrenergic reflex to laryngoscopy and intubation, most of the studies or the approach using different agents are aimed at blocking the effect of the reflex rather than preventing the stimulation starting from inducing agents thiopentone, propfol (6) analgesics, (7) different opioids, (8-9) beta blockers, (10-11) calcium channel blockers, (12-13) sodium channel blocker (14) and of late alpha2 agonists.
The classic (type 1) Brugada syndrome presents with the coved-type ST elevation in more than 1 right precordial lead, V1 through V3, with or without a sodium channel blocker, with one of the following criteria: syncope, documented ventricular fibrillation, electrophysiological inducibility of ventricular tachycardia, positive family history of cardiac death younger than age 45, nocturnal agonal respiration, self-terminating polymorphic ventricular tachycardia, and type 1 ST elevation in family members.
Patel has mentioned potential paraclinical measures to identify athletes at risk, including electrocardiography (ECG), 2-D echocardiogram, genetic testing, Holter monitoring, cardiac magnetic resonance imaging (MRI), tissue Doppler, sodium channel blocker challenge, and adenosine challenge test.
In the other clinical trial, the investigators reasoned that slowing the absorption of nebulized hypertonic saline by premedicating CF patients with amiloride, a sodium channel blocker, would enhance patient response by extending the duration of airway rehydration.
In the other clinical trial, investigators reasoned that slowing the absorption of nebulized hypertonic saline by premedicating CF patients with amiloride, a sodium channel blocker, would enhance patient response by extending the duration of airway rehydration.
The ECG manifestations of Brugada syndrome, when concealed can be unmasked primarily by sodium channel blocker administration but also during a febrile state or with vagotonic agents.
WEX Pharmaceuticals' lead product based on Tetrodotoxin (TTX), a highly selective sodium channel blocker, is in Phase III clinical development for the treatment of cancer-related pain.
Preclinical data for Z212, a novel oral sodium channel blocker with the potential to reduce neuropathic pain, has been published in the journal PAIN.
New Paper Published in PAIN Reports Preclinical Efficacy of Z212, a Novel Sodium Channel Blocker to Reduce Neuropathic Pain-
Food and Drug Administration (FDA) approval for Ranexa, a first-in-class late sodium channel blocker and the first anti-anginal drug class approved in 30 years.
Ralfinamide is a novel compound of the alpha-aminoamide family with potent sodium channel blocker properties.

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