Announced the initiation of a Phase 2 proof-of-concept clinical trial of APD334, an oral Sphingosine
1-Phosphate Subtype 1 receptor modulator for autoimmune diseases, being studied in this trial for the treatment of ulcerative colitis.
1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.
PDGF/PDGFR-B directs cell migration with both sphingosine
kinase activation and expression of endothelial differentiation gene-1 (Rosenfeldt et al.
org Results of the ongoing Phase 2 RADIANCE trial for RPC1063, an oral selective sphingosine
1-phosophate 1 receptor modulator, will be presented.
Fingolimod is in a class of medications called sphingosine
l-phosphate receptor modulators.
Erythrocytes store and release sphingosine
1-phosphate in blood.
Professor of biochemistry and associate director of the Institute for Stem Cell and Regenerative Medicine, Hannele Ruohola-Baker's lab originally identified the sphingosine
1-phosphate (S1P) pathway as a critical player in ameliorating muscular dystrophy in flies.
School of Medicine) introduce 34 chapters which comprise a review of current knowledge on the production, measurement, and health impacts of the lipid species lysophosphatidic acid (LPA) and sphingosine
Gilenya is the first oral therapy approved to treat relapsing forms of MS and the first in a new class of compounds called sphingosine
1-phosphate receptor (S1PR) modulators.
Gilenya is a sphingosine
1-phosphate receptor modulator, which reduces the frequency of clinical exacerbations and delays the accumulation of physical disability.
1] or sphingosine
kinases that convert sphingosine
to S1P suggest that this drag should be avoided during pregnancy (Massberg & von Andrian, 2009).
Volker Brinkmann, PhD, and scientists at Novartis reported that FTY720 specifically binds to sphingosine
1-phosphate (S1P) receptors--docking sites on T cells--to home in on them and keep them in the lymph nodes.