sphingosine


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Related to sphingosine: cerebroside, ceramide, sphingomyelin

sphin·go·sine

 (sfĭng′gə-sēn′)
n.
A basic, long-chain, unsaturated amino alcohol, C18H37NO2, that combines with lipids to form sphingolipids.

[German Sphingosin : Greek sphingos, genitive of sphinx, sphinx (from the mysteries it presented to early observers) + -ine.]

sphingosine

(ˈsfɪŋɡəsɪn; -ˌsiːn)
n
(Biochemistry) biochem a long-chain compound occurring in sphingomyelins and cerebrosides, and from which it can be released by hydrolysis. Formula: CH3(CH2)12CH:CHCH(OH)CH(NH2)CH2OH
[from sphingos-, from Greek sphingein to hold fast + -ine2]
References in periodicals archive ?
It is an oral and selective sphingosine 1-phosphate 1 (S1PR1) and 5 (S1PR5) receptor modulator in development for immune-inflammatory indications such as ulcerative colitis and Crohn's disease, in addition to multiple sclerosis.
Ozanimod is a novel, oral, selective sphingosine 1-phosphate 1 and 5 receptor modulator.
The compounds, sphingosine and dihydrosphingosine, were found to be at significantly lower concentrations in blood samples from multiple sclerosis patients.
De igual forma, las HDL tienen la capacidad de inhibir la apoptosis en celulas endoteliales mediante la activacion de la via Akt/eNOS, las cuales son activadas por apoA-I y la esfingosina 1- fosfato (S1P-1, sphingosine 1- phosphate) al unirse a sus receptores SR-BI y S1P-2, respectivamente.
6 Sphingosine 1 phosphate (SIP) plays an important role in the egress of T-cell lymphocytes from lymph nodes in the presence of an antigen.
Impairment of angiogenic sphingosine kinase-1/sphingosine-1-phosphate receptors pathway in preeclampsia.
Ceramidases, which are main component of ceramide pathway catalyze metabolism of proapoptotic ceramide to anti-apoptotic sphingosine and other fatty acids.
Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus.
There is also an association between levels of HDL and sphingosine 1-phosphate (S1P) that contributes to the antithrombotic effects of HDL.
Song JH, Kim M, Park SW, Chen SW, Pitson SM, Lee HT Isoflurane via TGF-betal release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules.
Ceramides are among the most significant sphingosine based lipids which plays an important role in various biological events.
Global Markets Direct's, 'Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) - Pipeline Review, H1 2016', provides in depth analysis on Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) targeted pipeline therapeutics.

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