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Related to sphingosine: cerebroside, ceramide, sphingomyelin


A basic, long-chain, unsaturated amino alcohol, C18H37NO2, that combines with lipids to form sphingolipids.

[German Sphingosin : Greek sphingos, genitive of sphinx, sphinx (from the mysteries it presented to early observers) + -ine.]


(ˈsfɪŋɡəsɪn; -ˌsiːn)
(Biochemistry) biochem a long-chain compound occurring in sphingomyelins and cerebrosides, and from which it can be released by hydrolysis. Formula: CH3(CH2)12CH:CHCH(OH)CH(NH2)CH2OH
[from sphingos-, from Greek sphingein to hold fast + -ine2]
References in periodicals archive ?
Announced the initiation of a Phase 2 proof-of-concept clinical trial of APD334, an oral Sphingosine 1-Phosphate Subtype 1 receptor modulator for autoimmune diseases, being studied in this trial for the treatment of ulcerative colitis.
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.
PDGF/PDGFR-B directs cell migration with both sphingosine kinase activation and expression of endothelial differentiation gene-1 (Rosenfeldt et al.
org Results of the ongoing Phase 2 RADIANCE trial for RPC1063, an oral selective sphingosine 1-phosophate 1 receptor modulator, will be presented.
Fingolimod is in a class of medications called sphingosine l-phosphate receptor modulators.
Professor of biochemistry and associate director of the Institute for Stem Cell and Regenerative Medicine, Hannele Ruohola-Baker's lab originally identified the sphingosine 1-phosphate (S1P) pathway as a critical player in ameliorating muscular dystrophy in flies.
School of Medicine) introduce 34 chapters which comprise a review of current knowledge on the production, measurement, and health impacts of the lipid species lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SIP).
Gilenya is the first oral therapy approved to treat relapsing forms of MS and the first in a new class of compounds called sphingosine 1-phosphate receptor (S1PR) modulators.
Gilenya is a sphingosine 1-phosphate receptor modulator, which reduces the frequency of clinical exacerbations and delays the accumulation of physical disability.
1] or sphingosine kinases that convert sphingosine to S1P suggest that this drag should be avoided during pregnancy (Massberg & von Andrian, 2009).
Volker Brinkmann, PhD, and scientists at Novartis reported that FTY720 specifically binds to sphingosine 1-phosphate (S1P) receptors--docking sites on T cells--to home in on them and keep them in the lymph nodes.

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