A pharmacophore, for example, as defined by the International Union of Pure and Applied Chemistry, is "an ensemble of steric
and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger (or to block) its biological response.
This carrier function is important because molecules such as 6PPD migrate very slowly due to the steric
In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about structural heterogeneity contained in a parameter that is exquisitely sensitive to molecular shape called residual dipolar coupling measured in steric
In the small intestine, the macromolecules cannot permeate through tight junctions of the intestinal cell wall because of multiple factors, including molecular size and steric
hindrance effects, and are vulnerable to further enzymatic and hydrolytic degradation.
The trends with the alcohols follow the trends of the isocyanates where the lower steric
hindrance of reactive moieties leads to larger heats of reaction.
The team also clarified aspects of the second major theory of olfaction, termed the "shape theory of olfaction", which suggests that steric
aspects of odorants are central in the so-called "hand-in-glove" or "lock and key" interaction of odors with odorant receptors.
By using suitable polymeric steric
stabilizer can prevent from the precipitation of conducting polymer particles .
A major breakthrough was the discovery of self-doped polyaniline; however, the material shows reduced mechanical stability and decreased conductivity due to steric
antibodies) very unlikely because of steric
hindrance that occurs following binding of a hapten to one binding protein.
High-performance dispersants also typically employ ethylene oxide chains to provide nonionic steric
Phe80 and Phe141 have been suggested to function as a steric
gate conferring substrate specificity for the enzyme (Petrotchenko et al.
It was used to calculate electrostatic, steric
and hydrophobic descriptors for the given set of molecules and to perform regression to build a model by selecting a set of descriptors that describe the activity of the molecule.