stop codon


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stop codon

n.
Any of three codons, UAA, UAG, or UGA, that signal the termination of the synthesis of a protein. Also called chain termination codon, termination codon.
References in periodicals archive ?
Direct sequencing of all 11 exons of PRKAR1A of this patient identified a 88 A to G mutation, which changes the initiator ATG to a GTG codon, abolishes the translational start codon but does not introduce a premature stop codon [Figure 1]e.
462-463CC insertion caused a frameshift mutation which both changed the amino acids after 23rd codon and generated a premature stop codon at position 56 (Figure 2C, Figure 3).
3) that is a frameshift mutation and expected to result in a premature stop codon.
precore stop codon mutations, basal core promoter mutations, deletions in the pre-S gene region) gradually increases with the progression of disease through the different clinical stages (1,2).
Nonsynonymous changes are colored according to the new amino acid state where blue is a positive amino acid, red is a negative amino acid, orange is a polar amino acid, green is a hydrophobic amino acid, gray is a neutral change to a similar amino acid, and black indicates a premature stop codon.
MLL2 and KDM6A mutations that are thought to be responsible for KS generally create an early stop codon and truncate the protein before it is functional.
A Q356X heterozygous mutation was found in exon 6 of the CYP11B1 gene, which has previously been described in patients with an 11-beta-hydroxylase deficiency, and an R384X heterozygous alteration was found in exon 7 that results in a premature stop codon, causing the formation of a truncated protein without biological activity (Figs.
At a protein level, this tetranucleotide deletion results in a disruption of the amino acid reading frame that causes arginine to be replaced by phenylalanine at position 358, with a resulting premature stop codon at position 373, p.
The elongation process continues until a stop codon in the mRNA is reached.
We report 3 cases with 1 homozygous and 2 heterozygous mutations at codon 37 causing a premature stop codon.