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Table 3: Standard Chemotherapies with Known Nephrotoxicity Risk Carboplatin Cisplatin Cyclophosphamide Gemcitabine Methotrexate Mitomycin Nitrosureas Pemetrexed Streptozocin Vinca alkaloids
Streptozocin in conjunction with doxorubicin or 5-flurouracil is approved for pancreatic NET, but is limited by its toxicity profile (21, 22).
11] The current combination chemothepary, which include streptozocin, 5-FU, cyclophosphamide or doxorubicin, has only genereated short-lasting response in fewer than 10% of patients.
2] Streptozocin Mitomycin Mitoxantrone Paclitaxel Moderate (30%-90% frequency Minimal (< 10% frequency of emesis) of emesis) Carboplatin Bevacizumab Cyclophosphamide < Bleomycin 1,500 mg/ [m.
Melatonin protects against streptozocin, but not interleukin-1B-induced damage of rodent pancreatic B-cells.
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
Examples of nitrosureas are Carmustine, Lomustine and Streptozocin.
Combination treatment with streptozocin and doxorubicin is the favored first-line therapy in advanced disease.
Drugs that might interfere with the results of monitoring tests Antineoplastic drugs Other drugs Azacitidine Atropine Busulfan Chloral hydrate Chlorambucil Chlordiazepoxide Cisplatin Chlorpromazine Cyclophosphamide Cimetidine Cytarabine Diazepam Dacarbazine Dobutamine Dibromodulcitol Dopamine Estramustine Ephedrine Floxuridine Fentanyl Fludarabine Haloperidol Fluorouracil Hydroxyzine Ifosfamide Meperidine Lomustine Metoclopramide Mercaptopurine Midazolam Methotrexate Morphine Streptozocin Pentobarbital Thiopeta Phenylephrine Prochlorperazine Promethazine Ranitidine Scopolamine Secobarbital Temazepam
These researchers also reported that some of the rats given streptozocin to induce diabetes and treated with aminoguanidine had an apparent increase in adenomas of the pancreas.
Scientists treated rats with the chemical streptozocin to create a study model that mimics some Alzheimer-like cognitive problems, including impaired memory and learning.