subtherapeutic


Also found in: Medical.

sub·ther·a·peu·tic

 (sŭb′thĕr-ə-pyo͞o′tĭk)
adj.
Below the dosage levels used to treat diseases: subtherapeutic feeding of penicillin to livestock.

sub′ther·a·peu′ti·cal·ly adv.

subtherapeutic

(ˌsʌbθɛrəˈpjuːtɪk)
adj
involving or relating to drug dosages administered at too low a level to produce a therapeutic effect(of a drug dosage) below the level necessary to treat disease, not powerful enough to have a therapeutic effect
References in periodicals archive ?
Furthermore, a lack of efficacy caused by efforts to circumvent patents protecting formulations or processes may result in subtherapeutic levels of medicines, resulting in obvious health risks.
The antibiotic dicloxacillin appears to markedly decrease international normalized ratio levels in patients taking warfarin, reducing the mean INR to subtherapeutic ranges in the majority who take both drugs concomitantly, according to a research letter to the editor published online July 20 in JAMA.
It's more expensive to raise an antibiotic-free bird than it is to raise a bird that you feed subtherapeutic levels of antibiotics.
Subtherapeutic use of antibiotics in pork production: Risks and alternatives.
No pharmacokinetic assessment was made, and subtherapeutic artesunate and dihydroartemisinin (as well as clindamycin, piperaquine, quinine, and doxycycline) blood concentrations cannot be excluded.
Three of these subjects were taking 25 mg amitriptyline daily, a dose considered subtherapeutic for the treatment of depression and potentially contributing to ongoing symptoms.
The auditor wrote that the patient with the known seizure disorder with subtherapeutic drug levels, not requiring a change in seizure medication or those and with no post ictal or neurological findings could be managed in the outpatient setting under observation status.
This study was mainly focused on the clinically relevant drug concentrations, thus subtherapeutic and therapeutic drug levels were used.
Evaluation of the clinical utility through assignment to subtherapeutic (<50 ng/mL), therapeutic (50-150 ng/mL), and supratherapeutic (> 150 ng/mL) classification is described, with categorical agreement of 95.
An upper limit of 90 mg/kg is becoming more widely accepted, (3) and the once-recommended daily dose of 60 mg/kg is now thought to be subtherapeutic.
The tetracyclines are allowed to be used for growth promotion for swine, poultry, and cattle; livestock species (swine, poultry, cattle) that are routinely exposed for extended periods to subtherapeutic doses of antimicrobial agents exhibited a significantly higher prevalence of resistance than the species (horses) that are typically exposed only to therapeutic doses for brief periods (Bogaard et al.