Furthermore, a lack of efficacy caused by efforts to circumvent patents protecting formulations or processes may result in subtherapeutic
levels of medicines, resulting in obvious health risks.
The antibiotic dicloxacillin appears to markedly decrease international normalized ratio levels in patients taking warfarin, reducing the mean INR to subtherapeutic
ranges in the majority who take both drugs concomitantly, according to a research letter to the editor published online July 20 in JAMA.
It's more expensive to raise an antibiotic-free bird than it is to raise a bird that you feed subtherapeutic
levels of antibiotics.
use of antibiotics in pork production: Risks and alternatives.
No pharmacokinetic assessment was made, and subtherapeutic
artesunate and dihydroartemisinin (as well as clindamycin, piperaquine, quinine, and doxycycline) blood concentrations cannot be excluded.
Three of these subjects were taking 25 mg amitriptyline daily, a dose considered subtherapeutic
for the treatment of depression and potentially contributing to ongoing symptoms.
The auditor wrote that the patient with the known seizure disorder with subtherapeutic
drug levels, not requiring a change in seizure medication or those and with no post ictal or neurological findings could be managed in the outpatient setting under observation status.
This study was mainly focused on the clinically relevant drug concentrations, thus subtherapeutic
and therapeutic drug levels were used.
Evaluation of the clinical utility through assignment to subtherapeutic
(<50 ng/mL), therapeutic (50-150 ng/mL), and supratherapeutic (> 150 ng/mL) classification is described, with categorical agreement of 95.
level of VPA would fail to control the epileptic seizure.
An upper limit of 90 mg/kg is becoming more widely accepted, (3) and the once-recommended daily dose of 60 mg/kg is now thought to be subtherapeutic
The tetracyclines are allowed to be used for growth promotion for swine, poultry, and cattle; livestock species (swine, poultry, cattle) that are routinely exposed for extended periods to subtherapeutic
doses of antimicrobial agents exhibited a significantly higher prevalence of resistance than the species (horses) that are typically exposed only to therapeutic doses for brief periods (Bogaard et al.