Even though oestrogen sulfamates were found to not have an oestrogenic activity in vitro and oestrogen sulfamates cannot bind the oestrogen receptor, EMATE remained unattractive for use against hormone- dependent breast cancer.
23 Research using tricyclic coumarin sulfamates identified the compound 667 COUMATE (also known as STX64 or BN83495).
Studies were conducted on a series of steroidal sulfamates and the compound 17-diisopropylcarbamoyl - 1,3,5(10),16-estratetraen-3-yl sulfamate, also called KW - 2581, was recognised as a potent steroidal-based selective STS inhibitor.
34 Recently, studies have also been conducted on letrozole-derived and vorozole-based sulfamates and new compounds have been identified with potential DASI properties.
Additional S-containing compounds are things such as reducing agents (lipoic acid and glutathione), antibiotics (penicillin), sugar sulfates (glucose sulfates), sulfamates
, and adenosine phosphosulfates.