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A sulfonamide antibiotic, C10H11N3O3S, that is used especially in combination with trimethoprim to treat bacterial urinary tract infections, other bacterial infections, and infections caused by certain fungi and parasites.


(ˌsʌl fə mɛθˈɒk səˌzoʊl)

an antimicrobial substance, C10H11N3O3S, used to treat urinary-tract and skin infections.
[1955–60; sulfa (nilamide) + meth (yl) + (is)oxazole]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.sulfamethoxazole - a sulfonamide (trade name Gantanol) used to treat infections (especially infections of the urinary tract)
sulfa, sulfa drug, sulfonamide, sulpha - antibacterial consisting of any of several synthetic organic compounds capable of inhibiting the growth of bacteria that require PABA


n sulfametoxazol m
References in periodicals archive ?
There was cross-reactivity with other sulfa antibiotics: Seven of 18 patients with prior sulfamethoxazole allergy reacted to oral challenge with sulfadiazine, and 4 of 9 patients with prior allergy with sulfamethoxazole reacted to challenge with sulfamethazine.
The starting point for Sulfamethoxazole are substances as common as sugar and sulphur.
Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim- sulfamethoxazole and doxycycline for maintenance therapy of melioidosis.
For instance, most of the polymorphs in the experiment could be made on any of several members of the 436-polymer library, but one of the two new forms of sulfamethoxazole grew on only one polymer.
In patients with normal kidney function, the elimination half-life of sulfamethoxazole is 9 h and that of trimethoprime is 10 h.
Within 112 days of their first or second febrile or symptomatic urinary tract infection (UTI), 302 young children diagnosed with vesicoureteral reflux (VUR) by voiding cystourethrogram were randomized to 3 mg of trimethoprim plus 15 mg of sulfamethoxazole per kilogram; and 305 other VUR children were randomized to placebo.
Compared with other antibiotic classes, sulfonamides, including the sulfamethoxazole that is contained in TMP/SMX, are responsible for higher rates of moderate-to-severe allergic reactions, hospitalizations, and hematologic or renal effects (5).
25 2 Clarithromycin ([dagger]) 23 8 4 Doxycycline 22 1 2-8 Imipenem 22 4 8 Linezolid 22 4 16 Sulfamethoxazole 21 4 32 Trimethoprim/ sulfamethoxazole 6 1/19 2/38 ([double dagger]) Tobramycin 23 [less than or 8 equal to] 2 Tigecycline 5 0.
Using concealed allocation, the children were randomly assigned to a control group that did not receive antibiotic therapy or an intervention group receiving sulfamethoxazole-trimethoprim (5-10 mg/kg sulfamethoxazole plus 1-2 mg/kg trimethoprim once daily) for 2 years, after which they stopped treatment but were monitored for another 2 years.