suppressor gene

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Related to suppressor gene: lethal gene, suppressor mutation
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Noun1.suppressor gene - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
gène suppresseur
References in periodicals archive ?
It appears to play a fundamental role in the operation of the p53 tumor suppressor gene, which is a focus of much modern cancer research.
Laiho's research linked the pathway to p53 gene activity; p53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.
The tumor suppressor gene p53 appears to play a key role in keeping cells healthy and preventing them from starting the abnormal growth that is a hallmark of cancer.
By activating a cancer suppressor gene, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.
Since the population is mostly female, males that inherit the suppressor gene would have many opportunities to breed and pass on the gene.
This approach has shown promise, for example, in our INGN 401 program, in which the FUS-1 tumor suppressor gene is administered intravenously to patients with metastatic lung cancers.
The p53(+/-) mouse has one functional wild-type allele and one inactivated allele of the tumor suppressor gene p53.
The goal of cancer treatment with CDK inhibitors is to emulate tumor suppressor gene behavior and cause cancer cells to die.
Dr Farida Latiff, at the University of Birmingham, has won a three-year funding package of pounds 128,561 to study the function of a suppressor gene and how it prevents lung cells becoming cancerous.
On the other hand, in the chapter on tumor suppressor genes in the main text, a brief explanation is provided for each tumor suppressor gene.
In a study published in the July issue of the American Journal of Obstetrics and Gynecology(2000;183:39-45), the investigators found that the test could be used to identify human papillomavirus E6 and the tumor suppressor gene p53, both of which are linked to the development of cervical cancer.