The gene variants called MC1R-RHC, which confer red hair and fair skin, also destabilize the tumor suppressor gene
It appears to play a fundamental role in the operation of the p53 tumor suppressor gene
, which is a focus of much modern cancer research.
Laiho's research linked the pathway to p53 gene activity; p53 is a tumor suppressor gene
, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene
The tumor suppressor gene
p53 appears to play a key role in keeping cells healthy and preventing them from starting the abnormal growth that is a hallmark of cancer.
By activating a cancer suppressor gene
, a small molecule called nutlin-3a can block cancer cell division, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health.
Since the population is mostly female, males that inherit the suppressor gene
would have many opportunities to breed and pass on the gene.
This approach has shown promise, for example, in our INGN 401 program, in which the FUS-1 tumor suppressor gene
is administered intravenously to patients with metastatic lung cancers.
The p53(+/-) mouse has one functional wild-type allele and one inactivated allele of the tumor suppressor gene
The goal of cancer treatment with CDK inhibitors is to emulate tumor suppressor gene
behavior and cause cancer cells to die.
Dr Farida Latiff, at the University of Birmingham, has won a three-year funding package of pounds 128,561 to study the function of a suppressor gene
and how it prevents lung cells becoming cancerous.
On the other hand, in the chapter on tumor suppressor genes
in the main text, a brief explanation is provided for each tumor suppressor gene
In a study published in the July issue of the American Journal of Obstetrics and Gynecology(2000;183:39-45), the investigators found that the test could be used to identify human papillomavirus E6 and the tumor suppressor gene
p53, both of which are linked to the development of cervical cancer.