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Any of various sacs, composed of synaptic vesicles and mitochondria, that break away from axon terminals at a synapse after brain tissue has been homogenized under controlled conditions.

syn·ap′to·so′mal adj.


(Physiology) physiol a saclike structure at an isolated nerve ending
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Synaptosome protein content was measured as described by Bradford (1976), using bovine serum albumin (BSA) as a standard.
Differential effect of anionic and cationic drugs on the synaptosome associated acetylcholinesterase activity of dog brain.
Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.
The goal was to find an instance in which the rat synaptosome sucked up everything but serotonin.
In fixed and rapid-frozen synaptosome samples, mean diameters were 47.
It is in high concentration in the electric organ of the electric eel, Eletrophorus Electricus, an adaptation of a synaptosome that depends on acetyl choline as the neurotransmitter.
With Torpedo, these detached terminals can be bulk-isolated by conventional subcellular fractionation and are recoverable in synaptosome fractions: such preparations have been widely used for biochemical studies (see Dowdall and Zimmermann, 1977; Michaelson and Sokolovsky, 1978; Morel et al.
The crude synaptosome was resuspended in 10 ml of HEPES--sodium buffer (NaCl: 140 mM; KCl: 5 mM; [NaHCO.
Reduced mitochondrial function was observed in in vivo synaptosome preparations, and although striatal dopamine levels were not decreased, there was an increased dopamine turnover and decreased motor activity.
In addition, seeking the active principles, the in vitro effects of all purified compounds were compared on monoaminergic uptake assays using synaptosome preparations of different brain regions.
1984) and later to characterize the brevetoxin binding site in rat brain synaptosome sodium channels (Poli et al.
Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics.