seeker desires innovative ideas and solutions for selectively targeting small molecules to the liver (specifically hepatocytes or hepatic stellate cells, but also kupffer cells and liver sinusoidal endothelial cells) whilst maintaining minimal drug levels in the systemic circulation
The composition of the microbiota largely determines the levels of tryptophan in the systemic circulation
and, indirectly, the levels of serotonin in the brain.
Children with HLHS have a functioning right ventricle, but have a small left ventricle that can't support the systemic circulation
Moreover, the kidney tissues of the mice from CME groups were harvested for HE staining to understand the distribution of the microspheres in the systemic circulation
P-glycoprotein acts as a cell membrane pump and increases the elimination of loperamide from the CNS and systemic circulation
We chose to measure bioavailability using area under the plasma concentration curve (AUC) because it accurately represents the total amount of unchanged active compounds that reach systemic circulation
0 heart pump is a catheter-styled blood pump, used for drug-resistant acute heart failure, such as cardiogenic shock, to support systemic circulation
by placing the device at left ventricle from a femoral artery insertion and expelling blood directly from left ventricle to ascending aorta.
The truncus arteriosus is characterized by the presence of a single arterial vessel emerging from the base of the heart and irrigates the coronary bed, the pulmonary circulation, the systemic circulation
, and usually presents interventricular communication.
gingivalis attain critical mass, they gain access to systemic circulation
via the bloodstream and neural pathways, The periodontal pathogens do this by disrupting the body's natural defenses.
The thicker wall of the (left) ventricle allows for stronger contractions to pump blood through the systemic circulation
Her team previously demonstrated that resveratrol--a polyphenol found in berries, nuts, grapes, and, famously, red wine--improves vasodilation in the systemic circulation
, so they wanted to see if would do the same in the brain (Nutr Metab Cardiovasc Dis.
Consider the contrast between these arterioles and their counterparts in the systemic circulation