telomerase


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te·lom·er·ase

 (tə-lŏm′ə-rās′, -rāz′)
n.
An enzyme that is found in the telomeres of chromosomes in germ cells, stem cells, and most cancer cells and that preserves the length of telomeres across cell divisions.

telomerase

(tɛˈlɒməˌreɪz)
n
(Biochemistry) an enzyme that is involved in the formation and repair of telomeres, so that chromosomes are not shortened during cell division

te•lom•er•ase

(təˈlɒm əˌreɪs, -ˌreɪz)
n.
an enzyme, active chiefly in tumors and reproductive cells, that causes telomeres to lengthen: facilitates cell division and may account for the immortality of cancer cells.
[telomere + -ase]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.telomerase - an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Translations
télomérase
References in periodicals archive ?
TEHRAN (FNA)- The telomerase enzyme is known to play a significant role in aging and most cancers.
The alteration occurs in the telomerase reverse transcriptase gene, which helps to produce the enzyme telomerase.
The telomerase activity is not detected in most somatic cells including normal hepatocytes but is detected in many cancer cells including HCC.
The enzyme telomerase is overexpressed in almost all cancer cells, and previous research efforts have failed to identify good telomerase inhibitors.
Washington, January 27 ( ANI ): An Indian origin scientist and his team analyzed the genomes of 14 family members who were affected by malignant melanoma and found an identical mutation in the gene for telomerase, an enzyme often called 'immortality enzyme', in all persons studied.
Researchers from the Republic of Korea isolated a population of stem cells derived from dental tissues of third molars and found that human dental papilla stem cells--DpaSCs that develop into dentin and dental pulp--have biological features similar to bone marrow-derived mesenchymal stem cells (MSCs) in terms of telomere length, telomerase activity and reverse transcriptase (Rtase) activity.
In a discovery that could have implications for new cancer therapies, a team of researchers led by Pascal Chartrand at Universite de Montreal's Department of Biochemistry have obtained the first real-time images showing the activity of a molecule called telomerase.
Different mutations in telomerase were found by screening patients and families with an inherited form of a disease called idiopathic pulmonary fibrosis (IPF).
The study was undertaken to determine the karyotype and telomerase expression levels at the time of diagnosis in 104 myelodysplastic syndrome (MDS)and138 acute non lymphocytic leukaemia (ANLL) patients and to correlate these abnormalities with different FAB subtypes.
Szostak, PhD, the Nobel Prize in Medicine, for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
The role of telomerase in allowing the immortal growth of reproductive cells is well established in the scientific literature.