teratogenicity


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ter·a·to·gen·ic

 (tĕr′ə-tə-jĕn′ĭk)
adj.
Of, relating to, or causing malformations of an embryo or fetus.

ter′a·to·ge·nic′i·ty (-jə-nĭs′ĭ-tē) n.
ter′a·to·gen′e·sis (-ĭ-sĭs) n.
Translations

teratogenicity

n teratogenicidad f
References in periodicals archive ?
Because of the risk of teratogenicity and to minimize fetal exposure, ABSORICA is available only through a restricted Program under a Risk Evaluation and Mitigation Strategy (REMS) called iPLEDGE[sup.
Developmental toxicity was observed in three animals: teratogenicity (mice), embryolethality (rats), and fetal growth restriction (rabbits).
Findings based on data collected before June 2013 and presented at a teratogenicity meeting last year were "not unblinded in terms of what medications were associated with what outcomes or who the controls were," she said.
Revised and updated, this edition includes the drugs perampanel and retigabine (ezogabine), updated pharmacokinetic interactions, suggested pediatric dosing schedules for several drugs, discussion of bone health and vitamin D monitoring and supplementation for selected drugs, additional adverse effects and recommended precautions and monitoring, and information on teratogenicity in the sections on pregnancy.
Cardiac teratogenicity of trichloroethylene metabolites.
Infants are usually less affected than mothers; nevertheless, selection of the mother's antimicrobial drug regimen must ensure adequate control of the bacteria while avoiding teratogenicity and in utero adverse effects, such as low birthweight (3,4).
The use of antidepressants is a cause of concern for physicians and their patients because of risks of teratogenicity, neonatal toxicity and long term behavioral effects.
These data provide welcome news for patients who can't take isotretinoin or don't want to, as well as for the many physicians reluctant to prescribe the drug because of the considerable regulatory hassles and potentially serious side effects, including teratogenicity.
Neither exposure to cigarette nor marijuana smoke has evidence for teratogenicity, but both have been implicated in developmental and hyperactivity disorders in children.
The National Institute for Occupational Safety and Health (NIOSH) defines hazardous drugs as drugs that have the following characteristics: carcinogenicity, teratogenicity or other developmental toxicity, reproductive toxicity, organ toxicity at low doses and genotoxicity.
Teratogenicity is the best-known serious adverse effect, and the risk of 'retinoid embryopathy' is as high as for thalidomide; mucocutaneous side-effects include initial worsening of acne, xerosis and cheilitis, retinoid dermatitis, and staphylococcal infections of the skin; ocular complications include dry eyes that can persist indefinitely; and severe depression can occur as a rare and idiosyncratic event requiring prompt attention.
The two major side effects of concern are the risk of teratogenicity and psychiatric changes, including depression.