thrombin


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Related to thrombin: antithrombin, Thrombin time

throm·bin

 (thrŏm′bĭn)
n.
A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.

thrombin

(ˈθrɒmbɪn)
n
(Biochemistry) biochem an enzyme that acts on fibrinogen in blood causing it to clot

throm•bin

(ˈθrɒm bɪn)

n.
an enzyme of the blood plasma that catalyzes the conversion of fibrinogen to fibrin, the last step of the blood-clotting process.
[1895–1900; thromb (us) + -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.thrombin - an enzyme that acts on fibrinogen in blood causing it to clot
coagulase - an enzyme that induces coagulation
Translations

throm·bin

n. trombina, enzima presente en la sangre extravasada que cataliza en la conversión de fibrinógeno en fibrina.
References in periodicals archive ?
It will acquire Recothrom Thrombin topical, the first and only stand-alone recombinant thrombin, and Preveleak Surgical Sealant, which is used in vascular reconstruction.
has agreed to acquire two hemostat and sealant products from Mallinckrodt pic: RECOTHROM Thrombin topical (Recombinant), a stand-alone recombinant thrombin, and PREVELEAK Surgical Sealant used in vascular reconstruction.
In view of deranged renal function CT angiogram was not done and decision was made to treat the pseudoaneurysm with percutaneous thrombin injection.
Thrombin is involved in the coagulation cascade by converting fibrinogen into fibrin, and increasing coagulative activity in the blood.
TF VIIa initiates a series of reactions supported by negatively charged phospholipids (PL) located on the surface of activated platelets that lead to thrombin generation and fibrinogen-to-fibrin conversion (Fig.
Thrombin is neutralized by its physiological inhibitor antithrombin; thus, the thrombin-antithrombin (TAT) complex is believed to be a reliable marker of in vivo thrombin generation [5].
The biologics (human thrombin and fibrinogen) react and initiate a fibrin clot, which then integrates into the patch, providing mechanical support and adherence to the wound site.
Some surgeons moisten gelatins with topical thrombin prior to use, though no trials exist evaluating the efficacy of this maneuver.
It downregulates coagulation by forming an irreversible inactive complex with thrombin and activated factor X (Xa).
The noninvasive diagnostic, relies on nanoparticles that detect the presence of thrombin, a key blood-clotting factor.
The main treatment options for symptomatic pseudoaneurysms include ultrasound-guided compression, percutaneous thrombin injection or surgical repair.
MECHANISM OF ACTION OF NEWER ANTICOAGULANTS: Thrombin-inhibiting drugs can block the action of thrombin by binding to three domains: the active site or catalytic site and two exosites.