A basic initial work-up includes a full blood count with peripheral blood smear review, prothrombin time/international normalised ratio and a partial thromboplastin time
The partial thromboplastin time
has been the gold standard for monitoring.
Prothrombin time and activated partial thromboplastin time
, albumin levels and alpha-1 antitrypsin value checked for liver failure were normal.
Institutions were asked to provide retrospective data related to the first plasma transfusion episode for 40 adult patients: the number of plasma units prepared for the patient, the number of plasma units transfused, the indication(s) for transfusion (chosen from a list), pretransfusion and posttransfusion coagulation test results (prothrombin time [PT], international normalized ratio [INR], activated partial thromboplastin time
[aPTT]), and occurrence and type of transfusion reaction.
Prolonged Prothrombin Time, Activated Partial Thromboplastin Time
and a normal platelet count pointed towards a disorder of coagulation.
5 s aPTT 128s 25-35 s Fibrinogen 495 mg/dL 175-400 mg/dL Factor II 5% 50%-150% Factor V 98% 50%-150% Factor VII 10% 50%-150% Factor IX 8% 50%-150% (a) PT, prothrombin time; aPTT, activated partial thromboplastin time
Previous studies have shown that in patients with SFTS, blood coagulation parameters are prolonged, as characterized by activated partial thromboplastin time
and thrombin time (9,10).
Material and Methods: Patients referred to the Nephrology Department for kidney biopsy were considered for inclusion in the study provided they did not have any contraindications to the procedure and had a normotensive state with BP less than 130/90 mm Hg and a normal coagulation profile including partial thromboplastin time
, prothrombin time, bleeding time and platelet count.
The activated partial thromboplastin time
(APTT) is a clot-based test of the intrinsic and common coagulation pathways.
lucidum in-vitro based on prothrombin time (PT) and activated partial thromboplastin time
At that time, she was admitted to the hospital, where lab tests showed prolonged prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time
(aPTT), and elevated D-dimer level, with a normal platelet count.
Laboratory results on hospitalization revealed anemia and elevated levels of fibrin degradation products (FDP), D-dimer, and fibrinogen (FIB), but prothrombin time (PT) and activated partial thromboplastin time
(aPTT) were within the normal range (Table 1).