AspirinWorks is the only FDA-cleared test that measures urinary thromboxane
B2 to accurately determine aspirin effect in apparently healthy individuals.
Differential regulation of prostaglandin E2 and thromboxane
A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors.
The patients who fell into the highest quartile for urinary thromboxane
level had 80% more events than the people in the lowest quartile for urinary thromboxane
(Circulation 105: 1650-55, 2002).
Thus, platelet factor 4, [beta]-thromboglobulin, serotonin, and thromboxane
Clinical laboratories that run the AspirinWorks Test use a combination of two codes: 84431 for thromboxane
metabolites (also known as AspirinWorks/11dhTxB2) and 82570 for the urinary creatinine measurement.
Platelet aggregation is a complex, multi-step process involving a number of signaling molecules--and soy isoflavones act to reduce the density of vital receptors for one such molecule, thromboxane
A2, in direct proportion to the isoflavone concentration in blood.
12,13) The specific inhibition of COX-2 alters the balance between platelet-derived thromboxane
ET-1 synthesis can be stimulated by epinephrine, thromboxane
, vasopressin, angiotensin, insulin, cytokines and physical factors such as changes of vascular wall shear force and pressure and hypoxia.
Although the level of thromboxane
A2 (TXA2) was not assessed, deficit of inhibiting TXA2 synthesis was suspected to cause extensive vasospasm.
Arterial vasodilators (reserpine, papaverine, tolazoline), specific thromboxane
inhibitors (methimazole, iloprost), and nonspecific thromboxane
inhibitors (aspirin, methylprednisolone) are also recommended to prevent edema, thrombosis, and vasospasm (6).
The tests evaluated levels of serum thromboxane
, which is associated with risk of blood clotting.
It is well known fact that larger the platelets, the more they are reactive because they produce more prothrombotic factors resulting in better aggregators to adenosine diphosphate (ADP), collagen or adrenaline and more thromboxane
A2 (TxA2) secretion.