It was the first time that an actual function of the thymus was proved, that being the maturation of certain immune T-cells (CD4 cells) by a particular protein which Beardsley named thymic
protein A (TPA).
For the dissection, we made a ventral midline incision of the skin at the cervical region, followed by a dilatation of the subcutaneous connective tissue, and then we removed the tissues adjacent to the thymic
We hypothesised that this could be due to increased T-cell turnover as a result of decreased thymic
output, as previously suggested.
AMG 157 is a human monoclonal antibody that blocks interaction of thymic
stromal lymphopoietin (TSLP) with the TSLP receptor.
The authors conclude that potential associations of in utero PCB exposure with thymic
development may be limited to the neonatal period, but thymus volume measures late in infancy may be affected by postnatal PCB expocures.
2) In fact, mice lacking one Bcl11b allele are susceptible to thymic
Despite the known association of thymectomy with YEL-AVD, the only observation on possible thymic
disease in the reports of the 9 cases is the statement that, at autopsy of a 22-year-old woman from the United States, the thymus was replaced by fat (Table 36-30 in 11).
One of these genes encodes the protein thymic
stromal lymphopoietin (TSLP), which plays a critical role in sensing environmental agents and triggering immune response.
The differential diagnosis of cystic cervical masses includes thyroid cyst, thymic
cyst, thyroglossal duct cyst, branchial cleft cyst, bronchogenic cyst, lymphangioma and parathyroid cyst (PC) (1).
The authors referred to this case as "partial" DiGeorge syndrome because the parathyroid and thymic
abnormalities were not as severe as those documented in other cases.
She returned to her native England in 2007 after being diagnosed with thymic
cancer, but eventually lost her battle on October 3.
The study was undertaken because uninfected children born to HIV-infected mothers typically have low CD4 counts, reduced thymic
output, and other immunologic abnormalities at birth.