thyroid-binding globulin

Also found in: Medical.
Related to thyroid-binding globulin: thyroxine-binding prealbumin

thy·roid-bind·ing globulin

n. Abbr. TBG
A glycoprotein to which thyroid hormone binds in the blood and from which it is released into tissue cells. Also called thyroxine-binding globulin.
References in periodicals archive ?
4] assays, it is preferable to use circulating total thyroxine as a measure of thyroid gland activity in pregnant women, because thyroid-binding globulin concentrations are elevated during pregnancy (Stagnaro-Green et al.
Thyroid-binding globulin (TBG) deficiency results in low serum total T4 levels; however, serum TSH and serum-free T4 concentrations are normal.
In human newborns PCP was found in spinal cord plasma and decreased levels of T3, free T4 and thyroid-binding globulin (a protein that transports T4).
During pregnancy, the thyroid increases in volume with an increase in thyroid-binding globulin (TBG) due to elevated estrogen levels, which then results in increased concentrations of total T4 and T3.
The most common causes were thyroid-binding globulin deficiency (200/548 or 36% of newborns with transient hypothyroidism), severe illness (36%), prematurity (8%), and errors in screening procedures (4%).
Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin.
12], cortisol, C-peptide, thyroid-binding globulin, dehydroepiandrostendione sulfate, and testosterone were measured by competitive immunoassays using limited immobilized antibodies and labeled hormones.

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