tonoclonic


Also found in: Medical.
Translations

ton·o·clon·ic

a. tonoclónico-a, rel. a espasmos musculares que son tónicos y clónicos.
References in periodicals archive ?
12,13) The mechanism of rhabdomyolysis in hemlock poisoning is via cicutoxin's antagonism of gamma-aminobutyric acid (GABA) with unopposed spasmodic contractions in striated muscles, tonoclonic seizures, myocyte disruption, and rhabdomyolysis with myoglobinuria.
23) Epileptogenic plants cause generalized tonoclonic seizure activity through several mechanisms, including massive nicotinic receptor stimulation (poison hemlock, wild tobacco), gamma-aminobutyric acid (GABA) antagonism in the CNS (water hemlock), postsynaptic inhibition of inhibitory glycine receptors in the spinal cord (strychnine), and profound hypoglycemia (imported unripe ackee or breadfruit tree fruit).
Nicotinic plant poisoning following ingestion of poison hemlock will result in initial CNS stimulation, with myoclonus and hyperreflexia progressing to generalized tonoclonic convulsions followed rapidly by weakness, paralysis, and respiratory failure.