tophus


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Related to tophus: hyperuricemia, gout

to·phus

 (tō′fəs)
n. pl. to·phi (-fī)
1. A deposit of urates in the skin and tissue around a joint or in the external ear, occurring in gout. Also called chalkstone.
2. A concretion of mineral salts and organic matter deposited on the surface of the teeth.

[Latin tōphus, tufa.]

tophus

(ˈtəʊfəs)
n, pl -phi (-faɪ)
(Pathology) pathol a deposit of sodium urate in the helix of the ear or surrounding a joint: a diagnostic of advanced or chronic gout. Also called: chalkstone
[C16: from Latin, variant of tōfus tufa, tuff]
tophaceous adj

to•phus

(ˈtoʊ fəs)

n., pl. -phi (-fī).
a calcareous concretion formed in the soft tissue about a joint, in the pinna of the ear, etc., esp. in gout.
[1545–55; < Latin tōphus, tōfus tufa]
to•pha•ceous (təˈfeɪ ʃəs) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tophus - a deposit of urates around a joint or in the external eartophus - a deposit of urates around a joint or in the external ear; diagnostic of advanced or chronic gout
urate - a salt of uric acid
2.tophus - an incrustation that forms on the teeth and gumstophus - an incrustation that forms on the teeth and gums
crust, encrustation, incrustation - a hard outer layer that covers something
Translations

to·phus

n. tofo.
1. depósito de sal de ácido úrico en los tejidos, gen. visto en casos de gota;
2. cálculo dental.

tophus

n (pl -phi) tofo
References in periodicals archive ?
Sufficient clinical criteria (if met, can classify as gout; then step 3 is not necessary): presence of MSU crystals in a symptomatic joint or bursa or the presence of tophus.
Patients also had to have at least one measurable tophus on the hands/wrists and/or feet/ ankles at least 5 mm in width and up to 20 mm in length.
The crystals then promote further degradation of the cartilage matrix through tophus formation and inflammation.
Target Tophus Size and Complete Response Rates In Patients Treated With Open-Label Pegloticase For Chronic Gout Refractory To Conventional Therapy; Abstract #1193 (Poster); Monday, October 28, 2013, 8:30am - 4:00pm PT
A solitary tophus which is seen as a soft tissue mass without inflammatory joint disease can be confused with neoplastic conditions.
Due to vascularization of the granulation tissue around the tophi, one might even see variable enhancement within the same tophus.
Clinical, radiological and laboratory criteria are helpful in the absence of MSU crystals in the aspirated joint fluid or tophus.
Although the rapid decline in his ambulatory status may not be explained completely by the chronicity of tophaceous gout, it does perhaps suggest that the tophus was undergoing a phase of acute inflammation, with cellular infiltration and inflammatory exudate formation, producing pain and resulting in a critical size increase, which was sufficient enough to produce clinical evidence of cord compression.
The differential diagnosis of a dermatofibroma (Table) includes neurilemmoma (or schwannoma) (8), neurofibroma, piloleiomyoma, cyst, hypertrophic scar, and tophus.
For patients with tophaceous deposits caused by gout, treatment with currently available therapies takes a period of years to achieve tophus resolution," said Herbert S.
Tophus (plural tophi): A hard deposit of crystalline uric acid that may appear as a lump just under the skin, particularly around the joints and at the rim of the ear.
Its 80 mg and 120 mg tablets are indicated for the treatment of chronic hyperuricemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).