topoisomerase


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Related to topoisomerase: DNA gyrase

to·po·i·som·er·ase

 (tō′pō-ī-sŏm′ə-rās′, -rāz′)
n.
Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands.

topoisomerase

(ˌtɒpəʊaɪˈsɒməreɪs)
n
(Biochemistry) biochem any of a class of enzymes that control the coiling of DNA molecules
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References in periodicals archive ?
Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3 or 5 DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent implications in tumourigenesis.
Also noteworthy was the overexpression of topoisomerase 2A and other markers, although these findings need to be correlated with outcome and response to chemotherapy.
DNA topoisomerase II (topo II) poison activity, was also evaluated using purified topo II and a supercoiled form of DNA that bears specific topo II recognition and binding region; topo II poisons stabilize normally transient DNA-topo II cleavage complexes, and lead an increased yield of linear form as a consequence of a lack of double-strand breaks rejoining.
A temporary exposure to a topoisomerase inhibitor in utero has the potential to have a long-lasting effect on the brain, by affecting critical periods of brain development.
Zylka said that a temporary exposure to a topoisomerase inhibitor in utero has the potential to have a long-lasting effect on the brain, by affecting critical periods of brain development.
Irinotecan and Topotecan are semisynthetic analogue of natural alkaloid Camptothecin ,and currently are the most widely used camptothecin analogs in clinical experiments that targets topoisomerase I enzyme.
Glaxo's new compound latches onto topoisomerase, which helps bacteria produce proteins and replicate.
The topics include the two-dimensional agarose gel electrophoresis of DNA topoisomers, single-molecule magnetic tweezer studies of type IB topoisomers, binding DNA topoisomers I and II to replication origins, assaying topoisomers II checkpoints in yeast, the cytological analysis of chromosome structural defects that result from topoisomers II dysfunction, and the depletion and mutation of topoisomerase II in animal cells.
Inspiralis Ltd make a range of products targeted to the pharmaceutical industry to enable drug-discovery work in this area including topoisomerase enzymes, themselves, as well as associated products.
A number of studies indicate the MLL bcr is susceptible to DNA cleaving agents, such as topoisomerase II (topo II) and DNase I, but there have been no reports of direct binding of such proteins in this region.
Savene(R) is a catalytic inhibitor of Topoisomerase II, an enzyme found in the cell nucleus.
Mutations in topoisomerase genes of fluoroquinolone-resistant salmonellae in Hong Kong.