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Noun1.trandolapril - an ACE inhibiting drug (trade name Mavik) used in some patients after a heart attack or to treat hypertension
ACE inhibitor, angiotensin-converting enzyme inhibitor - an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to treat congestive heart failure
References in periodicals archive ?
Ramipril, imidapril, perindopril, enalapril, lisinopril, benazepril, fosinopril, trandolapril, and quinapril dominate the ACEIs.
In 3717 patients who were randomized to trandolapril or placebo as part of the Prevention of Events with Angiotensin Converting Enzyme (PEACE) trial, increased concentrations of MR-proANP were independently associated with the risk of cardiovascular death or heart failure (HR per 1 SD, 1.
The post-hoc analysis focused on a subgroup of 8,354 patients from among the 22,576 total patients enrolled in the International Verapamil SR Trandolapril Study (INVEST), which enrolled patients aged 50 years or older with hypertension and preexisting coronary artery disease at 862 centers in 14 countries (JAMA 2003;290:2805-16).
lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril.
A clinical trial of the angiotensin-convertingenzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction.
The long-term impact of the angiotensin-converting enzyme inhibitor trandolapril on mortality and hospital admissions in patients with left ventricular dysfunction after a myocardial infarction: follow-up to 12 years.
25-20 Moderate Trandolapril 2, 15-24 (a) 1-8 Moderate Significantly binds ACE inhibitor tissue ACE Prodrug Benazepril No Yes Captopril No No Enalapril No Yes Fosinopril No Yes Lisinopril No No Moexipril Yes Yes Perindopril Yes Yes Quinapril Yes Yes Ramipril Yes Yes Trandolapril Yes Yes (a)Biphasic; pharmacokinetically has two peaks associated with two different half-lives.
ACE Inhibitors: benazepril, lisinopril, monopril, quinapril, ramipril, trandolapril
Some ACE inhibitors are known as "centrally-acting" because they can cross the blood-brain barrier- a specialized system of tiny blood vessels that protects the brain from harmful substances in the blood stream-that include captropril, fosinopril, perindopril, ramipril and trandolapril.
In brief, the PEACE trial was a double-blind, phase III trial that randomized patients with stable CAD and preserved left ventricular function to trandolapril vs placebo.
11 Percentage of patients who receive the ACE inhibitor trandolapril for the treatment of Hypertension