STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements.
The RelA NF-[kappa]B subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate
the c-myc promoter in mammary cells.
It was shown that c-Myc can possibly transactivate
the eIF5A2 gene [95, 96].
Remarkably, current studies have focused on the impact of p53 to transactivate
genes involved in aerobic metabolism.
HBX can transactivate
several signaling transduction pathways including protein kinase C, ras/raf/ MAP, Jak 1 kinase and src kinase.
macrophylla extracts are able to transactivate
the estrogen receptors [alpha] and [beta], in human embryonic kidney 293T cell line (HEK293T) .
Sp1 and Sp3 transactivate
the human lipoprotein lipase gene promoter through binding to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant.
Estrogens may bind to two types of receptors in target cells: estrogen receptor-alpha (ER-alpha) and ER-beta, both of which can transactivate
gene expression in target cells.
Transcription factors PPAR gamma and C/EBP have been shown to transactivate
some of the adipocyte-expressed genes.
Concerns that subsequently arose regarding a potential adverse impact on breast cancer risk and the growth of existing estrogen dependent tumours were predominantly triggered by findings from in vitro research as well as rodent studies showing that isoflavones bind to and transactivate
estrogen receptors (ERs) (Jefferson 2000, Muthyala 2004) and induce proliferation and estrogenic markers in MCF-7 cells (an ER positive breast cancer cell line) (Bodinet 2004, Ju 2001, Schmidt 2001).
These results suggested the biological function for PML-RAR[alpha] to transactivate
differentiation-related genes that are critical for therapeutic response of ATRA in APL.
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate
target genes and suppress transformation.