transactivate


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trans·ac·ti·vate

 (trăns-ăk′tə-vāt′, trănz-)
tr.v. trans·ac·ti·vat·ed, trans·ac·ti·vat·ing, trans·ac·ti·vates
To stimulate the transcription of (a gene in a host cell) by binding to DNA. Genes can be transactivated naturally by a virus or cellular protein or artificially by the insertion of a transactivator gene and segment of DNA into a cell.

trans′ac·ti·va′tion n.
trans·ac′ti·va′tor n.
References in periodicals archive ?
LncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements.
The RelA NF-[kappa]B subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells.
Remarkably, current studies have focused on the impact of p53 to transactivate genes involved in aerobic metabolism.
HBX can transactivate several signaling transduction pathways including protein kinase C, ras/raf/ MAP, Jak 1 kinase and src kinase.
macrophylla extracts are able to transactivate the estrogen receptors [alpha] and [beta], in human embryonic kidney 293T cell line (HEK293T) [18].
Sp1 and Sp3 transactivate the human lipoprotein lipase gene promoter through binding to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant.
Estrogens may bind to two types of receptors in target cells: estrogen receptor-alpha (ER-alpha) and ER-beta, both of which can transactivate gene expression in target cells.
Transcription factors PPAR gamma and C/EBP have been shown to transactivate some of the adipocyte-expressed genes.
Concerns that subsequently arose regarding a potential adverse impact on breast cancer risk and the growth of existing estrogen dependent tumours were predominantly triggered by findings from in vitro research as well as rodent studies showing that isoflavones bind to and transactivate estrogen receptors (ERs) (Jefferson 2000, Muthyala 2004) and induce proliferation and estrogenic markers in MCF-7 cells (an ER positive breast cancer cell line) (Bodinet 2004, Ju 2001, Schmidt 2001).
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.
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