C-Jun was shown to transactivate
SP-1-mediated induction of p21 resulting in mitotic arrest of ALK+ ALCL (Kardassis et al.
Chimeric proteins consisting of the DNA binding domain of the yeast transcription factor Gal4 and the ER[alpha] or ER[beta] hormone binding domain, which were transiently transfected in SkBr3 cells, showed a strong transactivation by E2 but not by atrazine (Figure 1E,F), confirming that atrazine did not transactivate
Estrogens may bind to two types of receptors in target cells: estrogen receptor-alpha (ER-alpha) and ER-beta, both of which can transactivate
gene expression in target cells.
RAF inhibitors transactivate
RAF dimers and ERK signalling in cells with wild-type BRAF.
Transcription factors PPAR gamma and C/EBP have been shown to transactivate
some of the adipocyte-expressed genes.
Concerns that subsequently arose regarding a potential adverse impact on breast cancer risk and the growth of existing estrogen dependent tumours were predominantly triggered by findings from in vitro research as well as rodent studies showing that isoflavones bind to and transactivate
estrogen receptors (ERs) (Jefferson 2000, Muthyala 2004) and induce proliferation and estrogenic markers in MCF-7 cells (an ER positive breast cancer cell line) (Bodinet 2004, Ju 2001, Schmidt 2001).
These results suggested the biological function for PML-RAR[alpha] to transactivate
differentiation-related genes that are critical for therapeutic response of ATRA in APL.
The authors suggest that abnormalities of proliferation regulation in endometrial tumors may be connected with accumulation of mutant p53 protein, its disability to transactivate
such target genes as p21, with changes in expression of p16 protein.
Notably, the proinflammatory transcription factor NF-[kappa]B has been shown to transactivate
lipocalin-2 expression through binding with a consensus motif in the promoter region of the lipocalin-2 gene (18), suggesting that this secretory protein might be involved in the inflammatory responses.
ATM targets p53 protein, a transcription factor that can bind to specific DNA sequences and transactivate
certain p53-responsive genes while DNA-PK targets mdm2.
Both Epstein-Barr viral nuclear antigen 2 (EBNA-2) and activated Notch1 transactivate
genes by interacting with the cellular protein RBP-J kappa.
PPAR-[gamma]2 is known as a master regulator of adipogenesis because of its ability to transactivate
adipogenic target genes such as aP2, GLUT4, fatty acid synthase, LPL, acetyl-CoA carboxylase, and steroyl-CoA desaturase (van Bilsen et al.