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 (trăns-ăk′tə-vāt′, trănz-)
tr.v. trans·ac·ti·vat·ed, trans·ac·ti·vat·ing, trans·ac·ti·vates
To stimulate the transcription of (a gene in a host cell) by binding to DNA. Genes can be transactivated naturally by a virus or cellular protein or artificially by the insertion of a transactivator gene and segment of DNA into a cell.

trans′ac·ti·va′tion n.
trans·ac′ti·va′tor n.
References in periodicals archive ?
The myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding.
Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition.
Transactivation of micrornA-320 by microRNA-383 regulates granulosa cell functions by targeting E2F1 and SF-1 proteins.
For example, an estrogen agonist MIE, as measured by in vitro estrogen receptor (ER) binding and estrogen receptor transactivation (ERTA) assays, can support a plausible mechanism for an observed increase in uterine weight of immature or ovariectomized female rats following chemical exposure and is assumed to be primarily mediated through ERa genomic signaling linked to cell proliferation and increased water imbibition (Figure 3).
Estrone sulfate and dehydroepiandrosterone sulfate: transactivation of the estrogen and androgen receptor.
Differential roles of C4 and C1 in mediating suppression of post-transcriptional gene silencing: evidence for transactivation by the C2 of Bhendi yellow vein mosaic virus, a monopartite begomovirus.
29 Furthermore, ZF2 is essential for the transactivation of the c-fos promoter, which is a main mechanism of activator protein 1 (AP1).
455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists
Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein.
The BG1Luc Estrogen Receptor (ER) Transactivation (BG1Luc ER TA) test method is aimed at the identification of potential estrogen receptor agonists and antagonists; i.
Among the topics are the transactivation domain of the p53 protein, the cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression, p53 and the carcinogenicity of chronic inflammation, p53 as an effector or inhibitor of therapy response, and exploiting the p53 pathway for therapy.
Another group contains an N-terminal caspase recruitment domain (CARD), and other group contains nucleotide-binding oligomerization domains (NOD) Other NLR family members contains an acidic transactivation domains.
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