94) Also, another study (95) suggests that an existing phenothiazine-like antipsychotic drug, trifluoperazine
, has the ability to down-regulate cancer stem cell markers CD44 and CD133 and as such might possess anti-lung cancer stem cell properties.
15,16] However, there is evidence for a range of other agents, including pregabalin, agomelatine, older antidepressants such as tricylics (TCAs), benzodiazepines, the azapirone buspirone, the antihistamine agent hydroxyzine, the first-generation antipsychotic trifluoperazine
and the second-generation antipsychotic quetiapine.
5-10 mg Medium Potency Trifluoperazine
Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Researchers from Case Western Reserve University School of Medicine and Mount Sinai School of Medicine found that the anti-psychotic medication trifluoperazine
can reactivate a gene pathway involved in tumor suppression that's normally turned off in lung cancer patients.
Besides matrix acidosis, the immunosuppressant cyclosporin A (16), its non-immunosuppressive analogues, N-methyl-valine cyclosporin and N-methylisoleucine cyclosporin (17), sanglifehrin A (18), bongkrekic acid (19), trifluoperazine
(20), magnesium, certain ubiquinone analogues (21) as well as volatile anaesthetic agents (22) and propofol (23) have all been shown to either block the open state or prevent assembly of the mPTP, thus preventing both necrotic and apoptotic cell death.
The other most commonly prescribed drugs were (in order) risperidone, haloperidol, olanzapine, chlorpromazine, trifluoperazine
, and quetiapine.
Drug Milligram equivalent to 20 Confidence mg of olanzapine (Zyprexa) Second generation antipsychotics Aripirazole (Abilify) 30 M Clozapine (Clozaril) 400 H Paliperidone (Invega) 9 M Quetiapine (Seroquel) 740 H Risperidone (Risperdal) 6 H First generation antipsychotics Haloperidol (Haldol) 10 H Perphenazine (Trilafon) 30 M Trifluoperazine
(Stelazine) 20 M Key: H = high confidence level; M = moderate confidence level.
Here he remained until age 13, on thioridazine and trifluoperazine
(doses unknown) when PPVT IQ of 55 led to transfer to a developmental center.
3%): the antipsychotic substances propericiazine, pipothiazine, trifluoperazine
, fluphenazine, flupenthixol, zuclopenthixol, olanzapine, clozapine, loxapine, amisulpride, and risperidone and the antidepressant substances tianeptine, dosulepine, viloxazine, paroxetine, citalopram, venlafaxine, and sertraline.
Related compounds, such as trifluoperazine
and perphenazine, also may have low teratogenic risk, although they are not as well studied as phenothiazine chlorpromazine.