tubocurarine


Also found in: Thesaurus, Medical, Wikipedia.

tu·bo·cu·ra·rine

 (to͞o′bō-ko͝o-rä′rĭn, -rēn′, -kyo͝o-, tyo͞o′-)
n.
1. An alkaloid that is an active component of curare obtained from the plant Chondrodendron tomentosum.
2. The hydrated chloride form of this alkaloid, C38H44Cl2N2O6, used as a drug to relax skeletal muscles during anesthesia.

[Latin tubus, tube (from the practice of shipping it in bamboo tubes) + curarine (curare + -ine).]

tubocurarine

(ˌtjuːbəʊkjʊˈrɑːriːn)
n
a toxic alkaloid obtained from the stem of a S American vine. Formula: C37H42Cl2N2O6

tu•bo•cu•ra•rine

(ˌtu boʊ kyʊˈrɑr in, -ɪn, ˌtyu-)

n.
the principal active alkaloid of curare, C38H44Cl2N2O, used as a muscle relaxant, esp. as an adjunct to anesthesia.
[1895–1900; < German Tubocurarin=Tubocurar(e) (see tube, -o-, curare) + -in -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tubocurarine - a toxic alkaloid found in certain tropical South American trees that is a powerful relaxant for striated muscles; "curare acts by blocking cholinergic transmission at the myoneural junction"
alkaloid - natural bases containing nitrogen found in plants
neuromuscular blocking agent - a substance that interferes with the neural transmission between motor neurons and skeletal muscles
phytotoxin, plant toxin - any substance produced by plants that is similar in its properties to extracellular bacterial toxin
References in periodicals archive ?
Among the established agents, tubocurarine, gallamine, and pancuronium exert significant cardiovascular effects; atracurium and mivacurium produce minor changes in cardiovascular variables whereas vecuronium and rocuronium are associated with a high degree of cardiostability.
Several significant modern drugs such as digitoxin reserpine tubocurarine ephedrine ergometrine atropine vinblastine and aspirin had their origins in traditional folk medicines [2 9].
Modern drugs like aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine are examples, which were originally discovered through observations of traditional cure methods of indigenous peoples.
Neuromuscular transmission which was suppressed by tubocurarine in the in vitro preparation could be briefly restored by application to the nerve of two or more very closely spaced stimuli; this occurred because of summation of endplate potentials.
Some of the useful plant drugs include vinblastine, vincristine, Taxol, Podophyllotoxin, camptothecin, digitoxigenin, gitoxigenin, digoxigenin, tubocurarine, morphine, codeine, aspirin, atropine, Pilocarpine, capsicum, Ellison, curcumin, artemesinin and ephedrine among others.
the skeletal muscle relaxant tubocurarine from Strychnos toxifera Bentham, and the antimicrobial compounds berberine and sanguinarine from divergent plant species including Berberis spp.
3 [micro]M), in a reversible but non-competitive manner, unlike the more potent nicotinic antagonist tubocurarine ([IC.
Chondodendron tomentosum is a native of South America and produces the alkaloid tubocurarine, the principal ingredient in curare.
1) Anesthetists in the Korean War exercised the added benefit of intravenous muscle relaxation with the introduction of succinylcholine and tubocurarine.