Effects of microRNA-29 on apoptosis, tumorigenicity
, and prognosis of hepatocellular carcinoma.
The majority of safety testing was conducted in nude rats subjected to thoracic SCI, providing a well-established model of the target clinical population, and additional tumorigenicity
studies were conducted in uninjured SCID/bg mice.
These new tissue-, cell-, or gene therapy-based products will likely require additional testing such as immunogenicity, tumorigenicity
, and biodistribution analyses to support product safety.
The potential for tumorigenicity
makes BPyV contamination of bovine serum, biologicals seeds and other raw materials used for manufacture of veterinary and human products a cause for concern.
Objective: "It is well documented that each human cancer has acquired a large number of mutations (50-500), some of which are drivers for tumorigenicity
, others of which are indolent passengers.
Inhibitory effect of caloric restriction on tumorigenicity
induced by 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo-[4,5-b] pyridine (PhIP) in the CD1 newborn mouse bioassay.
Previous studies have reported that alterations in adult stem cells contributed to the enhancement of tumorigenicity
(Strong et al.
ESCs are pluripotent cells but are limited by immune rejection, tumorigenicity
, and ethical problems .
It promotes tumorigenicity
by repressing stemnessinhibiting miRNAs); CCND2, cyclin D2 (cyclin D2 forms a complex with and regulates CDK4 and CDK6 in cell cycle G1/S transition.
Capability of urinary components to enhance ornithine decarboxylase activity and promote urothelial tumorigenicity
Inhibin Resistance is Associated with Aggressive Tumorigenicity
of Ovarian Cancer Cells.
95) If cells are kept too long in culture and undergo chromosomal alterations, some studies have found this increases their risk of tumorigenicity