staining is usually positive in FTLD-FUS (aFTLD-U), is positive in some of the inclusions found in FTLD-FUS (NIFID), and is usually negative in FTLD-FUS (BIBD).
We incubated 100 [micro]L of each urine sample with added ubiquitin
(1 [micro]mol/L) for different times at room temperature.
Targeting of host-cell ubiquitin
-like pathways by bacterial factors.
The patents cover methods for identifying and/or measuring ubiquitin
ligase activity in any disease state and screening for agents that modulate their activity using any of the major enzymes in the ligase pathway as well as particular enzymes.
Within cells, ubiquitin
identifies and attaches to proteins that are ripe for degradation and removal.
Using the technique previously applied in the titin experiments, Fernandez pulled on one end of a gold-anchored ubiquitin
From that observation, the research team developed an infertility detection method using an antibody that combines exclusively with ubiquitin
USP 7 is an enzyme that removes a tag called ubiquitin
from proteins and stabilizes the expression of those proteins in the cell.
The research team headed by Jun Aruga has shown for the first time that a ligase named Rines (RING finger-type E3 ubiquitin
ligase) regulates these levels.
Researchers in the University of Leicester's Department of Biology discovered that chloroplasts are affected by the ubiquitin
proteasome system (UPS) -- a process which causes the breakdown of unwanted proteins in cells, previously thought to only act on central parts of the cell.
It is aimed at advancing new small molecules that function through the ubiquitin
proteasome system, modulating specific protein levels for therapeutic benefit.
signalling is predominantly mediated by polyubiquitin chains of distinct linkages.