Akiskal's "rule of three" conceptualization, which identified behavioral markers tied to bipolarity, proved effective in evaluating and differentiating patients with bipolar disorder from those with unipolar depression
However, being an author was specifically associated with increased likelihood of schizophrenia, bipolar disorder, unipolar depression
, anxiety disorders, substance abuse, and suicide," the authors wrote.
Questions relate to basic neuroscience, psychosis and antipsychotics, unipolar depression
and antidepressants, bipolar disorder and mood stabilizers, anxiety and anxiolytics, pain and the treatment of fibromyalgia and functional somatic syndromes, disorders of sleep and wakefulness and their treatment, and attention deficit hyperactivity disorder, dementia, and substance use disorders and their treatment.
This can develop into a chronic illness called recurrent unipolar depression
Here we review the evolving concept of bipolar spectrum disorders with particular reference to dimensional aspects of symptoms and the interfaces between unipolar depression
and bipolar disorder and between bipolar disorder and psychosis.
Fourth, the difficult differential diagnosis between bipolar and unipolar depression
is hardly mentioned.
Previous antemortem and postmortem tissue fatty acid composition studies have observed significant deficits in the omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3) in red blood cell (RBC) and postmortem cortical membranes of patients with unipolar depression
From October 2005 to January 2009, 432 male and female participants with major unipolar depression
were recruited to take part in this randomized, double-blind study (neither patients nor researchers knew which capsules patients received).
For ease of analysis, the diagnoses were clubbed together in five broad groups (ICD-10 codes): psychoses (F2029), bipolar disorder (F30-31), unipolar depression
(F32-34), obsessive compulsive disorder (OCD) (F42) and remaining diagnostic groups (others).
They address personality and mood disorders, the relationship between depression and medical illness, bipolar and unipolar depression
, risk factors, models of depression, genetics, neural biological aspects, the regulation of emotion, depression and early adverse experiences, children of depressed parents, cognitive aspects, interpersonal contexts, and the role of social environment and life stress in developing depression.
Bipolar disorder is a chronic illness associated with substantial morbidity and mortality, ranking worldwide behind only unipolar depression
and alcohol abuse among psychiatric illnesses for related disabilities and overall economic burden of illness.
The marketing research priority of the survey was to identify what proportion of the diagnosed unipolar depression
population in the US should have been diagnosed with bipolar depression, and to determine the key drivers of misdiagnosis.