The sBLA is based on a Phase III randomized, double-blind, placebo-controlled, multicenter 184 subject trial, which met both of its co-primary endpoints for subjects administered 100 U incobotulinumtoxinA by achieving statistically significant change in unstimulated
salivary flow rate, and in the subjects' Global Impression of Change Scale.
whole saliva samples were collected at the fasting state, in the morning, by passive spitting into containers over 15 minutes.
In all groups, unstimulated
whole salivary flow rate was determined.
The samples were then placed in fresh human unstimulated
saliva for 2 min to form an initial pellicle layer and facilitate the uptake of stain, and they were washed with water.
Saliva is usually categorized as unstimulated
(resting) or stimulated.
and/or PHA and PWM mitogen stimulated cell cultures were prepared as described above.
The Company has now completed TE-7 and perfomed an initial, unstimulated
, open hole well test of the first 28% of the gross reservoir interval.
The effect of aging on salivary flow is still unclear, and it seems that it is mainly the unstimulated
salivary flow rate that is affected (10).
Whereas, other five wells without Con-A served as unstimulated
Subsequently, ECM protein-derived signaling effects on the transcriptional regulation of SSC-specific genes were analyzed in unstimulated
pSSCs or those stimulated with laminin or collagen IV.
Results: The average stimulating threshold for RLNs stimulated with 15 mA and 20 mA showed no significant changes compared to the unstimulated
RLNs (15 mA group: 0.
In flavor preference tests, AGRP neuron activation reduced an animal's preference for previously preferred flavored gel compared to unstimulated
controls, suggesting that a once tasty flavor was now a less pleasant experience.