uricase


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uricase

(ˈjʊərɪˌkeɪz)
n
(Biology) an enzyme found in organisms from bacteria to mammals but absent in humans
References in periodicals archive ?
The analysis (Pegloticase, a Mammalian Uricase, Significantly Decreases Mean Arterial Blood Pressure in Patients with Chronic Gout; abstract FR-PO582) was presented at the American Society of Nephrology (ASN) Kidney Week 2017, Oct.
Serum creatinine was determined using the principle of Jaffe reaction as described by Bonsnes and Tausslay [20], while serum urea was determined by the kit (Quinica Clinica Spam), the Uricase method as described by Wootton [21].
A recombinant uricase or xanthine oxidase inhibitor is preferred to maintain the serum urate level below 300 [micro]mol/L Emergency management is required for patients with confirmed acute uric acid nephropathy.
catalase, tyrosinase, peroxidase, and uricase, functioning as a cofactor
10) The difference in absorbance before and after incubation with uricase is proportional to the uric acid concentration.
In this procedure uric acid is oxidized with the uricase, and in the presence of the generated hydrogen peroxide, a phenolic compound and 4-aminoantipyrine forms a red-colored quinoneimine and the absorbance of the quinoneimine chromagen, measured by spectrophotometry, is directly associated with the amount of uric acid in the sample (Thomas 1998).
Uric acid was originally measured in serum at visit 2 (1990-92) at the University of Minnesota using the Coulter DACOS system using an uricase measurement procedure (interassay CV = 2.
It was revealed that uricase inhibi-tor produce hyperuricemia, that initiated hypertension and reduced nitric oxide generation in the macula den-sa.
Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies J Rheumatol.
Veronese, "Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine)," II Farmaco, vol.
Pegloticase is a pegylated recombinant uricase that converts uric acid to allopurinol.
1) This loss of uricase and the consequential higher serum uric acid (sUA) levels observed in humans may contribute to the development of this disease in individuals.