Sixty-five metabolites were quantified, six of which could be related to early post-injury degenerative changes: isobutyrate, glucose, hydroxyprolyne, asparagine, serine, and uridine
Glycine and uridine
prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells.
Standard substance of cordycepin, adenosine, guanosine and uridine
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2]; 3: Lactate (Lac); 4: Alanine (Ala); 5: Glutamine (Gln), Glutamic acid (Glu); 6: Creatine (Cr); 7: Choline (Cho), Phosphocholine (PC); 8: Glycerophosphocholine (GPC); 9: Taurine (Tau); 10: Glycine (Gly); 11: [beta]-Glucose ([beta]-Glc); 12: Uridine
5'-diphospho-N- acetylglucosamine or Uridine
5'-diphospho-N-acetylgalactosamine (UDP); 13: Nicotinamide adenine dinucleotide 2'- diphosphate ([NADP.
2]); UGT, uridine
5'-diphospho- glucuronosyltransferase enzyme inducers (eg, rifampin, phenytoin, phenobarbital, ritonavir).
The objectives of the present study included (1) to identify through ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) and high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-SPE-NMR) the WEL metabolites formed in rats following an oral administration of 50 mg/kg WEL; (2) to determine the uridine
diphosphate-glucuronosyltransferases (UGTs) responsible for WEL glucuronidation using human liver microsomes (HLMs), human intestine microsomes (HIMs), human kidney microsomes (HKMs), and recombinant human UGT enzymes; and (3) to explore the possible mechanisms of WEL regioselective glucuronidation.
Furthermore, IAP dephosphorylates uridine
diphosphate (UDP), a nucleotide that upregulates the expression of IL-8, which is released into the gut by the host under inflammatory conditions (Moss et al.
A peptide unit is built on NAM (N-acetyl-muramic acid) while the sugar is attached to uridine
Codeine mainly metabolizes to codeine-6-glucuronide (C6G) by uridine
diphosphate glucuronosyl transferase (UGT2B7); but codeine can also undergo metabolism to morphine in the liver via cytochrome P450 2D6 (CYP2D6).
Cultured sample were incubated in 37[degrees]C for 30 hours by respectively adding Uridine
, 5-fluordeoxyuridine, thymidine and 5-bromodeoxyuridine materials in sterile conditions.
12), (4) and uridine
diphosphate galactose-4'epimerase (GALE, EC 5.
RNA molecules contain four standard nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine