diphosphate galactose-4-epimerase deficiency.
A 48-week randomized study of uridine
A unique combination of nutrients including omega-3 polyunsaturated fatty acids (docosahexaenoic acid, DHA and eicosapentaenoic acid (EPA)), uridine
monophosphate (UMP)) and choline, together with phospholipids and B vitamins.
The team also created a system that would cause yeast cells to edit the mRNA, replacing the uridine
in the codon that signals a halt in protein production with pseudouridine.
Repligen Corporation (Waltham, MA) announced that it has exclusively licensed worldwide rights for the use of uridine
in the treatment of patients with bipolar disorder from McLean Hospital.
UGT encodes the drug's main metabolizing enzyme in the body, uridine
Raltegravir is primarily metabolised by glucuronidation via uridine
diphosphate glucuronosyltransferase (UGT) 1A1.
In this paper, Lassmann and colleagues have evaluated the predictive value of five molecular markers associated with the metabolism of fluoropyrimidines [thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), uridine
phosphorylase (UP) and uridine
-cytidine kinase (UK)] and three molecular markers associated with cell proliferation and anti-apoptosis (Bcl-2-related protein, survivin and cyclin-D1).
The addition of dichloroallyl lawsone (DCL) to leukemic cells results in a rapid depletion of uridine
and cytidine nucleotides; carbamyl aspartate and dihydroorotate accumulate to high levels in an equilibrium ratio of 20.
2], L-arginine, uridine
, coenzyme Q10, idebenone, and triglycerides have been shown to provide alternate energy sources.
Newer studies are trying to correct mitochondrial depletion through the use of the supplement uridine
, which has been shown effective in treating mitochondrial toxicity caused by d4T and AZT (zidovudine or Retrovir).
Mutations were noted in uridine
kinase (gi29654198) in ST18, ST22, ST23, ST25, and ST29; in ompA-like transmembrane domain protein (gi29654257), in ST20; in rhodanese-like domain protein (gi29654263) in ST20 (the protein was longer by 2 amino acids); in dioxygenase (gi29654325) in ST21 and ST22; in hypothetical protein (gi29732244), in ST17.