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1. A membrane-bound organelle in the cytoplasm of most cells, especially plant cells, containing water and dissolved substances such as salts, sugars, enzymes, and amino acids.
2. A small extracellular cavity or space within tissues.

[French, from Latin vacuus, empty; see vacuum.]

vac′u·o′lar (-ō′lər, -lär′) adj.
vac′u·o·la′tion n.


(ˌvæk yu əˈleɪ ʃən, -yəˈleɪ-)

1. the formation of vacuoles.
2. the state of being vacuolate.
3. a system of vacuoles.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.vacuolation - the state of having become filled with vacuolesvacuolation - the state of having become filled with vacuoles
condition, status - a state at a particular time; "a condition (or state) of disrepair"; "the current status of the arms negotiations"
References in periodicals archive ?
Paraptosis is characterized by progressive swelling of mitochondria, endoplasmic reticulum (ER) and cytoplasmatic vacuolation.
Vacuolation, necrosis and varying degree of necrosis is seen along with loss of brush-border is evident (Figure-2).
2005), working with Araucaria angustifolia (Parana pine) callus, observed some elongated vacuolated cells, with vacuolation defined as an early marker of cell death (FILONOVA et al.
Liponeurocytoma is a circumscribed tumor of the cerebellum (Figure 4), composed of small neurocytic cells, some of which have prominent cytoplasmic vacuolation (Figure 5).
Other findings within the central nervous system included multifocal vacuolation and separation of white matter fibers consistent with spongiosis throughout the spinal cord.
CP causes histopathologically reduction in size and number of the seminiferous tubules, degeneration and vacuolation in spermatogonia, spermatocytes and less number of germ cells, irregular seminiferous tubules, reduced seminiferous epithelial layers and significant maturation arrest (Atessahin et al.
These include inhibition of spermatogenesis, disappearance of spermatozoa and spermatogenic cyst and higher incidence of pathological alterations such as fibrosis, vacuolation, and atrophy of germinal epithelium.
Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
The process is defined based on changes in cellular morphology and biochemical features, including DNA fragmentation, cytoplasm vacuolation, plasma membrane blebbing, and apoptotic body formation (49).
Firstly, it is directly toxic to developing cells, causing an increased or high-normal MCV and vacuolation of erythroid precursors.