valdecoxib


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Related to valdecoxib: rofecoxib, Parecoxib
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Noun1.valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tractvaldecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
Translations

valdecoxib

n valdecoxib m
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References in periodicals archive ?
The novel Cox-2 inhibitor Parecoxib hydrochloride, the only injectable of Cox-2 selective inhibitor, a prodrug of valdecoxib is being developed for the management of postoperative pain in various surgical procedures.
40 al, 2010 (18) ized Drugs: controlled Naproxen trials Etoricoxib Rofecoxib Valdecoxib Chung, et Random- 4 1,180 -12.
Analgesics like rofecoxib and valdecoxib, the COX-2 inhibitors can cause thrombi formation which increases the risk of cardiovascular events Hepatic [17,20] Hepatotoxicity occurs after the patient ingests 150 to 250 mg/kg of paracetamol as a single dose.
3] have reported that the blocking of cox-2 activity in cAD rats by valdecoxib (specific cox-2 inhibitor) resulted in better recovery of memory impairment, oxidative stress, and acetylcholine esterase activity compared to that of nonspecific cox blocker, naproxen, in a 25-day study indicating an important role of cox-2 on the colchicine induced memory impairments and stress parameters.
2]) provided the rationale for the development of COX-2 selective NSAIDs, such as celecoxib, rofecoxib, and valdecoxib, for the management of pyrexia, relief of pain, and alleviation of inflammation with less gastrointestinal side effects [2].
3) The findings of this meeting led to the withdrawal of valdecoxib from the market and labeling changes for prescription and nonprescription NSAIDs regarding increased risk of CV events and gastrointestinal (GI) bleeding.
Celecoxib, roficoxib, parecoxib, and valdecoxib are among the members of this class.
Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation.
Another study conducted by the Gibofsky who compared the efficacy of the NSAIDS valdecoxib and naproxen for the treatment of backache and compared it with placebo showed a reduction in pain upto 58.
In addition, the off-label promotion of the arthritis drug valdecoxib (Bextra), the epilepsy drug gabapentin (Neurontin), and the schizophrenia drug olanzapine (Zyprexa) resulted in criminal prosecutions, fines and settlements of hundreds of millions of dollars, and a record-setting settlement of US$2.
These include rofecoxib (Vioxx), valdecoxib (Bextra), and sibutramine (Meridia).
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.