In addition, the off-label promotion of the arthritis drug valdecoxib
(Bextra), the epilepsy drug gabapentin (Neurontin), and the schizophrenia drug olanzapine (Zyprexa) resulted in criminal prosecutions, fines and settlements of hundreds of millions of dollars, and a record-setting settlement of US$2.
These include rofecoxib (Vioxx), valdecoxib
(Bextra), and sibutramine (Meridia).
Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib
and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation.
Complications of the COX-2 inhibitors parecoxib and valdecoxib
after cardiac surgery.
Understandably, this discovery precipitated a careful review of all NSAIDs, whether COX-1 inhibitors (including ibuprofen) or COX-2 inhibitors (celecoxib, valdecoxib
, etoricoxib)--but it did not lead to greater scrutiny of acetaminophen.
Parecoxib (Pfizer, Sydney, NSW) is a selective COX-2 inhibitor (5-7) and a prodrug which is rapidly metabolised to valdecoxib
after parenteral administration (8-10).
ve non selektif NSAII icin kardiyovaskuler toksisite konusunda ise kesin kanit yoktur (11,12).
The study suggested an increased risk of stroke with rofecoxib (Vioxx) and valdecoxib
(Bextra), compared with the effects of nonselective agents (Stroke 2008;39:2037-45).
The drug samples, PAR, TAM and valdecoxib
were obtained as gift samples from the Alpha Remedies Limited, Hingna, Nagpur, Technica Labs & Pharma Private Limited, Dehradun, Uttarakhand and Emcure Pharmaceuticals Pvt.
For example, such popular and widely prescribed drugs as troglitazone, cerivastatin, rofecoxib, valdecoxib
, and cisapride were withdrawn from the market.
Classification of NSAIDs according to COX-selective properties COX-1 selective Non-selective COX-2 selective Indomethacin Diclofenac Celecoxib Piroxicam Naproxen Etoricoxib Lornoxicam Ibuprofen Parecoxib * Tenoxicam Nabumetone Rofecoxib ([dagger]) Ketoprofen Sulindac Valdecoxib
([dagger]) Ketorolac Lumiracoxib ([dagger]) Mefenamic acid Meloxicam * Parenteral formulation only ([dagger]) Withdrawn from the market, including South Africa.
Rofecoxib and valdecoxib
, highly selective COX-2 inhibitors, were recently withdrawn from the market because of adverse effects.