Using an electron microscope, he found what he thought were traces of smallpox, also known as variola virus
, in its remains.
The 6 orthopoxviruses variola virus
, vaccinia virus (VACV), camelpox virus, monkeypox virus, ECTV, and CPXV are recognized as originating from the Eurasian continent and are referred to as Old World orthopoxviruses (6).
Smallpox is an infectious disease caused by variola virus
that has killed millions of people over the centuries.
The researchers sent samples from a 17th century mummified child to a colleague in Canada, who uncovered remnants of variola virus
that causes smallpox, which once ravaged most of the world.
int/csr/disease/smallpox/faq/en/) World Health Organization , for instance, states that smallpox, caused by the Variola virus
, has existed for at least 3,000 years.
Target System Bacillus anthracis T1 JBAIDS Bacillus anthracis T2 JBAIDS Brucella JBAIDS Burkholderia JBAIDS Coxiella burnetii JBAIDS Eastern equine encephalitis virus JBAIDS Francisella tularensis JBAIDS Influenza virus A and B JBAIDS Influenza virus A SUBTYPING (H) JBAIDS Orthopox Viruses JBAIDS Rickettsia prowazekii JBAIDS Variola virus
JBAIDS Venezuela equine encephalitis virus JBAIDS Western equine encephalitis virus JBAIDS Yersinia pestis T1 JBAIDS Yersinia pestis T2 JBAIDS Influenza virus A and B ABI 7500 Influenza virus A SUBTYPING (H) ABI 7500 Norovirus SEROGROUP 1 ABI 7500 Norovirus SEROGROUP 2 ABI 7500 Table 4.
The sequence of camelpox virus shows it is most closely related to variola virus
, the cause of smallpox.
Although closely related to the variola virus
that causes smallpox, it is generally harmless to humans.
During decades, VACV was used as the vaccine strain in the world programme of eradication of smallpox, due to its low virulence and antigenic similarity with the agent of smallpox, variola virus
(VarV) (BAXBY, 1977).
Smallpox is caused by the variola virus
, an ancient pathogen that naturally infects humans and no other species.
Although naturally occurring variola virus
has been eradicated, stored samples are known to exist in the United States and Russia, and undeclared samples may exist elsewhere.
immune evasion design: expression of a highly efficient inhibitor of human complement.