Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts
While previous studies showed that MPA induces receptor activator of nuclear factor kappa-B ligand (RANKL) expression in rodent mammary gland, MPA reduced levels of RANKL in human tumor xenografts
have been attempted since 1905, the development of new transplant technologies has led some to proclaim a new "xenograft
era" (American Medical News, 13 August 1992).
A potent inhibitor of c-Met in multiple human cancer lines, ARQ 197 also was shown to inhibit growth of human tumor xenografts
7]) in culture medium were subcutaneously injected into the flanks of mice, Animals-bearing tumors were randomly assigned to treatment groups (6 mice per group) and treatment initiated when xenografts
reached volumes of about 100 [mm.
He added, "However, a very exciting development was our discovery that PNT2258, in combination with Rituximab, demonstrated curative events in treating Daudi xenografts
of human Burkitt's Lymphoma in mice.
Angiolix has been shown to achieve more than 75% growth inhibition of human breast cancer growing as xenografts
in mouse models.
Iacobelli will review recent data from in vivo studies in human Multiple Myeloma xenografts
in SCID/NOD mice demonstrating that Defibrotide increases the responsiveness of Multiple Myeloma cells to cytotoxic chemotherapeutics, such as Melphalan or Cyclophosphamide.
Data in human cancer cell lines, human-mouse xenografts
and cancers resistant to cyclophosphamide and ifosfamide indicated ZIO-201 was active at doses similar to those achieved in the phase I trial.
The data also show that anti-cancer activities of ZIO-201, ZIO-202, and ZIO-203 are similar in human pancreas and prostate cancer xenografts
and that many schedules were active.
CuraGen Corporation --"Treatment parameters modulating regression of human melanoma xenografts
in situ by an antibody-drug conjugate (CR011-vcMMAE) targeting gpNMB-expressing tumor cells" (Abstract A70)
Insert's lead anti-cancer drug, IT-101, has achieved complete remission of non-small cell lung cancer and Ewing's sarcoma, and significant knockdown of other tumor types in preclinical results in mouse xenografts
, showing promise across a wide range of cancers.