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zafirlukast

   Also found in: Medical, Wikipedia 0.01 sec.
za·fir·lu·kast  (z-fîrl-kst)
n.
A drug that acts as a leukotriene receptor antagonist, reduces the inflammatory process, and is used to treat the signs and symptoms of asthma.
[zafir-, of unknown origin + -lukast, leukotriene receptor antagonist suff. (from rearrangement of (anti)as(thmatic) l(e)uk(otriene receptor antagonis)t).]
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The FDA, which issued the call in mid June, said the reported neuropsychiatric events included cases of agitation, aggression, anxiety, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal ideation and behavior, and tremor in patients using montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo, Zyflo CR).
Agency calls for warnings on leukotriene inhibitors by Bullock, Lorinda / Clinical Psychiatry News
Montelukast and zafirlukast are LTRAs that block the actions of leukotrienes, thereby preventing airway hypersensitivityincreased mucus secretion, and increased vascular permeability by alleviating airway inflammation.
Asthma medications by Wojciechowski, Bill / FOCUS: Journal for Respiratory Care & Sleep Medicine
Leukotriene modifiers Montelukast (Singulair--MSD) and zafirlukast (Accolate--Astra Zeneca) are LTRAs, which are the most recently introduced class of anti-asthma agents.
It is important to recognise the inflammatory nature of asthma by Feldman, Charles / CME: Your SA Journal of CPD
 
 
 
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