zalcitabine

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zal·ci·ta·bine

(zăl′sĭ-tə-bīn′)

A nucleoside analog antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase. Also called ddC.

[zal- (perhaps alteration of (de)s- variant of de- + al(cohol), from the missing hydroxyl groups of cytidine) + -citabine, nucleoside analog antiviral and anticancer drug suff. (from shortening and alteration of cytarabine, an anticancer drug, blend of cytosine arabinoside, compound containing arabinose).]

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Noun

zalcitabine - an antiviral drug used to combat HIV infection

DDC, dideoxycytosine

antiviral, antiviral agent, antiviral drug - any drug that destroys viruses

Translations

zalcitabine

n zalcitabina

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References in periodicals archive ?

SHL and LA are related to the use of nucleoside reverse transcriptase inhibitors (NRTIs), occurring most frequently with zalcitabine, stavudine (d4T), didanosine, zidovudine (AZT), and lamivudine and least frequently with abacavir/tenofovir.

Mutations of mtDNA polymerase-[gamma] and hyperlactataemia in the HIV-infected Zulu population of South Africa

Several cases of ototoxicity have been reported in HIV infected patients treated with zalcitabine (Martinez and French, 1993); didanosine (Colebunders, Dipraetere, Van Wanzeele, and Van Gehuchten, 1998); zidovudine and didanosine (Christensen et al, 1998); stavudine, lamivudine, didanosine and hydroxyurea (Simdon et al, 2001); and post exposure prophylaxis with stavudine, lamivudine and nevirapine (Rey et al, 2002).

Effect of anti-retroviral therapy (ART) on hearing in HIV positive patients

Peripheral neuropathy is mainly seen with stavudine, didanosine, and zalcitabine.

Adverse drug events due to antiretroviral therapy in a northern Indian tertiary care institution

Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease.

Safety profile of antiretroviral therapy: an urgent need for monitoring

LHON following the introduction of the strongly mitochondrial toxic nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine, stavudine and zalcitabine (ddC) has previously been reported in patients with the mitochondrial mutations 11778G>A and 14484T>C.

Antiretroviral therapy-induced Leber's hereditary optic neuropathy

For instance, both zalcitabine and didanosine may cause tingling or pain in the hands, feet and legs, so they shouldn't be prescribed together.

HIV/AIDS

The drugs documented to most often be associated with pill esophagitis in HIV are zidovudine (azidothymidine), zalcitabine, and doxycycline.

Human immunodeficiency virus-related gastrointestinal pathology: a southern Africa perspective with review of the literature (Part 2: neoplasms and noninfectious disorders)

dagger]) Patient was receiving monotherapy with zalcitabine.

Hepatitis E virus infection in HIV-infected persons

peripheral neuropathy) is another complication of chronic alcohol abuse and, given their neuropathic side effects, limits the use of the NRTIs zalcitabine and stavudine in alcoholics (Moyle and Sadler 1998).

Alcohol's role in HIV transmission and disease progression

48-50) Similar presentations can occur with other nucleoside analog reverse transcriptase inhibitors, such as didanosine, lamivudine, and zalcitabine.

Drug-induced myopathies

Zidovudine, didanosine, zalcitabine, stavudine, and lamivudine all got the FDA green light before clinicians could craft a regimen with drugs from two classes.

Ten thoughts on how HIV care may change in 10 years

Then in 2001, lamivudine (3TC), stavudine (D4T), zalcitabine (DDC), didanosine (DDI), and indinavir (IDV) were produced.