zalcitabine


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zal·ci·ta·bine

 (zăl′sĭ-tə-bīn′)
n.
A nucleoside analog antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase. Also called ddC.

[zal- (perhaps alteration of (de)s- variant of de- + al(cohol), from the missing hydroxyl groups of cytidine) + -citabine, nucleoside analog antiviral and anticancer drug suff. (from shortening and alteration of cytarabine, an anticancer drug, blend of cytosine arabinoside, compound containing arabinose).]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.zalcitabine - an antiviral drug used to combat HIV infection
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
Translations

zalcitabine

n zalcitabina
References in periodicals archive ?
He was also a co-developer of some of the first effective drugs for the treatment of AIDS (zidovudine, AZT; didanosine, ddI; and zalcitabine, ddC).
LHON following the introduction of the strongly mitochondrial toxic nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine, stavudine and zalcitabine (ddC) has previously been reported in patients with the mitochondrial mutations 11778G>A and 14484T>C.
The drugs documented to most often be associated with pill esophagitis in HIV are zidovudine (azidothymidine), zalcitabine, and doxycycline.
dagger]) Patient was receiving monotherapy with zalcitabine.
peripheral neuropathy) is another complication of chronic alcohol abuse and, given their neuropathic side effects, limits the use of the NRTIs zalcitabine and stavudine in alcoholics (Moyle and Sadler 1998).
48-50) Similar presentations can occur with other nucleoside analog reverse transcriptase inhibitors, such as didanosine, lamivudine, and zalcitabine.
Zidovudine, didanosine, zalcitabine, stavudine, and lamivudine all got the FDA green light before clinicians could craft a regimen with drugs from two classes.
Potency estimations in vitro gave a descending hierarchy of their potency: zalcitabine, didanosine, stavudine, zidovudine and, finally, abacavir, as least toxic [28].
Kim and Chien (15,16) studied the effect of NMP on the skin permeation of the anti-HIV drugs zalcitabine, didanosine, and zidovudine using hairless rat skin at 37[degrees]C.
Which of the following viral proteins is the primary target for the cytidine analogues--lamivudine, zalcitabine, and emtricitabine?
1) Esophageal ulcerations associated with zalcitabine and zidovudine (2) have been reported.
The three drugs are didanosine (ddI), zalcitabine (D4T) and idovudine (AZT).