zalcitabine


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zal·ci·ta·bine

 (zăl′sĭ-tə-bīn′)
n.
A nucleoside analog antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase. Also called ddC.

[zal- (perhaps alteration of (de)s- variant of de- + al(cohol), from the missing hydroxyl groups of cytidine) + -citabine, nucleoside analog antiviral and anticancer drug suff. (from shortening and alteration of cytarabine, an anticancer drug, blend of cytosine arabinoside, compound containing arabinose).]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.zalcitabine - an antiviral drug used to combat HIV infection
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
Translations

zalcitabine

n zalcitabina
References in periodicals archive ?
SHL and LA are related to the use of nucleoside reverse transcriptase inhibitors (NRTIs), occurring most frequently with zalcitabine, stavudine (d4T), didanosine, zidovudine (AZT), and lamivudine and least frequently with abacavir/tenofovir.
Several cases of ototoxicity have been reported in HIV infected patients treated with zalcitabine (Martinez and French, 1993); didanosine (Colebunders, Dipraetere, Van Wanzeele, and Van Gehuchten, 1998); zidovudine and didanosine (Christensen et al, 1998); stavudine, lamivudine, didanosine and hydroxyurea (Simdon et al, 2001); and post exposure prophylaxis with stavudine, lamivudine and nevirapine (Rey et al, 2002).
Peripheral neuropathy is mainly seen with stavudine, didanosine, and zalcitabine.
Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease.
LHON following the introduction of the strongly mitochondrial toxic nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine, stavudine and zalcitabine (ddC) has previously been reported in patients with the mitochondrial mutations 11778G>A and 14484T>C.
For instance, both zalcitabine and didanosine may cause tingling or pain in the hands, feet and legs, so they shouldn't be prescribed together.
The drugs documented to most often be associated with pill esophagitis in HIV are zidovudine (azidothymidine), zalcitabine, and doxycycline.
dagger]) Patient was receiving monotherapy with zalcitabine.
peripheral neuropathy) is another complication of chronic alcohol abuse and, given their neuropathic side effects, limits the use of the NRTIs zalcitabine and stavudine in alcoholics (Moyle and Sadler 1998).
48-50) Similar presentations can occur with other nucleoside analog reverse transcriptase inhibitors, such as didanosine, lamivudine, and zalcitabine.
Zidovudine, didanosine, zalcitabine, stavudine, and lamivudine all got the FDA green light before clinicians could craft a regimen with drugs from two classes.
Then in 2001, lamivudine (3TC), stavudine (D4T), zalcitabine (DDC), didanosine (DDI), and indinavir (IDV) were produced.