zaleplon


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zaleplon

n zaleplón m, zaleplon m
References in periodicals archive ?
Sleep maintenance is an attractive indication in an underserved market and zaleplon is an excellent choice for delayed-release development.
The newer nonbenzodiazepine benzodiazepine receptor agonists (BRAs)--eszopiclone (Lunesta), zolpidem (Ambien), and zaleplon (Sonata)--are specific for the sedating benzodiazepine receptor.
For initial insomnia--or if the patient awakens some nights but not others--the short half-life of zaleplon (Sonata) makes it a good choice.
25 2 to 4 Immediate-release nonbenzodiazepines Eszopiclone 1 to 3 5 to 7 Zaleplon 5 to 20 1 Zolpidem 5 to 10 1.
This underscores the importance of appropriately assessing and treating elderly patients with sleep problems using the behavioral therapies and/or medications, particularly the newer short-acting nonbenzodiazepines--zolpidem (Ambien), zaleplon (Sonata), and eszopiclone (Lunesta)--with demonstrated efficacy in this setting, he said.
In a literature review comparing clinical effectiveness of zaleplon, zolpidem, or zopiclone (Z drugs) with the benzodiazepines diazepam, loprazolam, lorazepam, lormetazepam, nitrazepam, and temazepam, improvement in total sleep time was similar with all agents but zopiclone, which was slightly superior (Hum Psychopharmacol.
Somnus"), a private specialty pharmaceutical company that is developing controlled-release formulations of zaleplon to prevent MOTN awakening.
FDA-approved sedatives include non-benzodiazepines such as zolpidem, zolpidem extended-release, zaleplon, or eszopiclone, and the melatonin receptor agonist ramelteon.
Options include temazepam, triazolam, zolpidem, and zaleplon.
Verster et al (13) examined residual effects of benzodiazepines and the nonbenzodiaz-epines zolpidem, zopiclone (available in the United States as eszopiclone), and zaleplon on driving ability, as reported in studies of on-the-road driving, driving simulators, epidemiologic data, and closed-road driving.
Most agents approved by the Food and Drug Administration to treat insomnia work through the GABA-ergic system, including zolpidem (Ambien) or zaleplon (Sonata).
Indiplon, a [gamma]-aminobutyric acid (GABA) receptor agonist, is highly selective for the [alpha]-1 receptor subtype, a mechanism of action similar to zolpidem (Ambien) and zaleplon (Sonata).