In the last 10 to 15 years, as regenerative organisms like zebrafish
have become genetically tractable to study in the lab, I became convinced that these animals might be able to teach us what is possible for human regeneration, Pomerantz said.
When the researchers treated zebrafish
with a morpholino that targets the egfl7 gene, the fish developed blood vessel defects.
The compounds, known as epoxyeicosatrienoic acids, or EETs, boosted stem cell engraftment in both zebrafish
and mice and could make human bone marrow transplant more efficient.
For the first time, the researchers reveal how this niche forms, using time-lapse imaging of naturally transparent zebrafish
embryos and a genetic trick that tagged the stem cells green.
Professor Brunhilde Wirth, Head of the Institute of Human Genetics, University of Cologne, Germany, said that in most of their recent research, they have started out by using zebrafish
embryos in which PLS3 was knocked-out and studying their development at the three and five day-old stage.
Previously, we developed transgenic zebrafish
that specifically report ER transcriptional activity in all tissues of embryos and larvae with single cell resolution (Gorelick and Halpern 2011).
It has previously been shown that zebrafish
are able to discriminate between colors, even some not recognized by other commonly used laboratory animals.
explained that zebrafish
were increasingly being used in place of rodents to screen drugs for rare genetic disorders.
The Edinburgh University team studied zebrafish
because they share more than 80% of the genes associated with human diseases.
are ideal for studying the early stages of disease development, including MS.
Squid and zebrafish
can both change colour to attract mates and to frighten off predators.
The morphological and molecular basisof tissue and organ development in zebrafish
embryos resembles that of humans, and the overall drug toxicity is also comparable with that observed in animals.