(redirected from 1,25-dihydroxycholecalciferol)
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 (kăl′sĭ-trī′ôl′, -ōl′)
The active metabolite of vitamin D, C27H44O3, that is synthesized in the kidneys and liver from vitamin D2 or vitamin D3 and acts as a calcium-regulating hormone. A synthetic form is used as a drug to treat hypocalcemia, bone disease caused by renal failure, and, in topical preparations, psoriasis.



n calcitriol m
References in periodicals archive ?
3] Insulin secretion is impaired by vitamin D deficiency and restored by 1,25-dihydroxycholecalciferol administration.
The endocrine function involves the production of hormones like renin, prostaglandins, erythropoietin, and 1,25-dihydroxycholecalciferol.
The effect of dietary cholecalciferol, 25- hydroxycholecalciferol and 1,25-dihydroxycholecalciferol on the development of tibial dyschondroplasia in broiler chickens in the absence and presence of disulfiram.
1,25-dihydroxycholecalciferol, vitamin D3 performs an important role in maintaining calcium homeostasis in the bone, liver, intestine and parathyroid gland [1].
1-hydroxylase found primarily in the kidney resulting in the formation of 1,25-dihydroxycholecalciferol.
Cholecalciferol is hydroxylated to 25-hydroxycholecalciferol in the liver; 25-hydroxycholecalciferol is then transformed by the kidneys to the hormonally active metabolite calcitriol, 1,25-dihydroxycholecalciferol (1,25-[(OH).
1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis.
Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol.
Kulturun yedinci gununde olgunlasan noronlar uc gruba bolundu: Vitamin D uygulanan grup; yedinci gun, 24 ve 48 saat sureyle etanol icinde cozundurulen 10-8 M 1,25 dihidroksivitamin D3 (calcitriol, 1,25-dihydroxycholecalciferol, Sigma C-9756.
The enzyme 1a-hydroxylase, which activates vitamin D to 1,25-dihydroxycholecalciferol, is also stimulated, which results in increased Ca absorption from the intestines (Costanzo, 2006), because 1,25-dihydroxycholecalciferol may enhance the synthesis of calcium binding proteins (Kumar, 1995) and calcium channels in the enterocyte (Bouillon et al.
Correction of enhanced Na(+)-H+ exchange of rat small intestinal brush-border membranes in streptozotocin-induced diabetes by insulin or 1,25-dihydroxycholecalciferol.