calcitriol

(redirected from 1,25-dihydroxycholecalciferol)
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cal·ci·tri·ol

 (kăl′sĭ-trī′ôl′, -ōl′)
n.
The active metabolite of vitamin D, C27H44O3, that is synthesized in the kidneys and liver from vitamin D2 or vitamin D3 and acts as a calcium-regulating hormone. A synthetic form is used as a drug to treat hypocalcemia, bone disease caused by renal failure, and, in topical preparations, psoriasis.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Translations

calcitriol

n calcitriol m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Alteration in VDR expression and activity may lead to decreased levels of serum 1,25-dihydroxycholecalciferol, its uptake and metabolism (Alimirah et al., 2011).Vitamin D insufficiency is a common clinical problem in breast cancer patients.
Effect of 1,25-dihydroxycholecalciferol on sarcoplasmic reticulum calcium transport in strontium-fed chicks.
It is known that normal calcium absorption in the intestines and normal bone mineralization are dependent on 1,25-dihydroxycholecalciferol. Once synthesized on the skin by UV rays from 7-dehydrocholesterol, cholecalciferol (vitamin D3) is converted to 25-hydroxy-cholecalciferol in the liver, and then to 1,25-dihydroxy-cholecalciferol in the mitochondria of renal proximal tubule cells.
Daleprane, "Activation of Nrf2-antioxidant signaling by 1,25-dihydroxycholecalciferol prevents leptin-induced oxidative stress and inflammation in human endothelial cells," The Journal of Nutrition, vol.
The absorption of calcium from the intestinal tract by active transport and the reabsorption of calcium by the kidney is based mainly on the action of 1,25-dihydroxycholecalciferol or calcitriol (active vitamin D).
Abbreviations PHPT: Primary hyperparathyroidism HPT: Hyperparathyroidism PTH: Parathyroid hormone US: Ultrasound DTC: Differentiated thyroid cancer PTC: Papillary Thyroid Carcinoma FNAB: Fine needle aspiration biopsy 25(OH)D3: 25-Hydroxyvitamin D or cholecalciferol 1,25(OH)2D3: 1,25-Dihydroxycholecalciferol. Data Availability
[3] Insulin secretion is impaired by vitamin D deficiency and restored by 1,25-dihydroxycholecalciferol administration.
The endocrine function involves the production of hormones like renin, prostaglandins, erythropoietin, and 1,25-dihydroxycholecalciferol. The metabolic function enables the degradation of hormones and other biologically active compounds.
Friedman, "Effects of 1,25-dihydroxycholecalciferol administration on the rat renal vitamin K-dependent carboxylating system," FEBS Letters, vol.