gamma-butyrolactone

(redirected from 1,4-lactone)
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gam·ma-bu·tyr·o·lac·tone

 (găm′ə-byo͞o′tə-rə-lăk′tōn′)
n. Abbr. GBL
A chemical that has many industrial uses, especially as a solvent. It is a chemical precursor to gamma-hydroxybutyrate and is ingested illegally for its euphoriant and sedative effects.
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References in periodicals archive ?
The compounds 4 (IC50 = 4.06 0.34 M), 5 (IC50 = 09.63 0.81 M), 1 (IC50 = 19.66 0.44 M), 7 (IC50 = 24.75 0.25 M), 6 (IC50 = 26.30 1.37 M), and 3 (IC50 = 32.11 0.89 M), showed AY-glucuronidase inhibitory activity superior to the standard D-saccharic acid 1,4-lactone, with (IC50 = 48.4 1.25 M).
Indeed, another example incorporating thieno[2,3-b]thiophene core was found to be a potent [beta]-glucuronidase inhibition ([IC.sub.50] = 0.003 [+ or -] 0.09 [micro]M) several hundred fold more active than standard D-saccharic acid 1,4-lactone ([IC.sub.50] = 45.75 [+ or -] 2.16 [micro]M) [6, 7].
Wachowicz, "Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins," Nutrition, vol.