Babovic, "In vitro increased natural killer cell activity of metastatic melanoma patients with interferon-a alone as opposed to its combination with 13-cis retinoic acid
is associated with modulation of NKG2D and CD161 activating receptor expression," Journal of BUON, vol.
So far, chemopreventive agents which have been tested in clinical trials for oral pre-cancer lesions include vitamin A, isotretinoin (13-cis retinoic acid
), beta-carotene, cyclooxygenase-2 (COX-2), bowman-brick inhibitor concentration, erlotinib, green tea extract, freeze-dried black raspberry (BRB) and special medicinal herbs.
Isotretinoin, also known as 13-cis retinoic acid
, is commonly used as a potent remedy for cystic acne.
Conclusion: 13-cis Retinoic acid
has not shown a significant role in the reversal of tamoxifen induced changes in the uterine tissue after a short term administration of three months.
Thiboutot, "TRAIL contributes to the apoptotic effect of 13-cis retinoic acid
in human sebaceous gland cells," British Journal of Dermatology, vol.
With the pioneering 13-CIS Retinoic Acid
Treatment, Ryan is now into his fourth month of being disease free.
The treatment of severe cystic acne with 13-cis retinoic acid
. J Am Acad Dermatol 1980; 3: 602-11.
The most efficacious acne treatment, 13-cis retinoic acid
(RA) or Roaccutane[R], is well known for causing considerable improvement in very severe acne conditions (for example acne conglobata) but usage is also limited by its potential teratogenic effects.
Preliminary results with radioprotectors such as amifostine  and glutamine  and chemopreventive agents such as 13-cis retinoic acid
[66,67] and interferon alfa [66,67] have also been encouraging.
Treatment that combined isotretinoin (13-cis retinoic acid
) with alpha interferon reduced tumors in 16 of 26 patients with squamous cell carcinoma of the head and neck.
In an NCI study, persons with large numbers of skin tumors were fed a vitamin A-related compound, called 13-cis retinoic acid
. While receiving the synthetic nutrient, patients had dramatic reductions in the number of new skin tumors.