hydroxylase

(redirected from 18-hydroxylase)
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hydroxylase

(haɪˈdrɒksɪˌleɪz)
n
(Biochemistry) an enzyme useful in hydroxylation
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References in periodicals archive ?
ASD type I (CMO type I) is caused by a deficiency in the 18-hydroxylase enzyme, which results in low levels of OHB and aldosterone and low urinary metabolites; in ASD type II (CMO II), 18- OHB levels are markedly elevated, and the levels of aldosterone and its urinary metabolites are low [3].
Beginning from 11-deoxycorticosterone in the zona glomerulosa of the adrenal cortex, aldosterone synthase catalyzes the sequential activities of 11[beta]-hydroxylase, 18-hydroxylase, and, finally, 18-methyl oxidase, the final three steps in aldosterone synthesis (1,2).
CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18).