The selected congeners were 1,2,3,7,8-pentachlorodibenzo-p-dioxin (congener 1), 2,3,7,8-tetrachlorodibenzo-p-dioxin
(congener 2), 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (congener 3) and 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (congener 4).
Teratology Studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-P-dioxin
. Toxicology and Applied Pharmacology, 20: 396-403.
Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin
Glover et al., "Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin
toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor," The Journal of Biological Chemistry, vol.
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin
exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology.
Exposure and human health reassessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) and related compounds.
And penta sold in the United States for uses such as preserving utility poles must now be manufactured under conditions that do not produce 2,3,7,8-tetrachlorodibenzo-p-dioxin
and that minimize the concentration of another toxic congener, 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin.
One of the worst dioxins is 2,3,7,8-tetrachlorodibenzo-p-dioxin
Thus, one picogram of the most toxic of the dioxins - 2,3,7,8-tetrachlorodibenzo-p-dioxin
(2,3,7,8-TCDD) represents approximately 2 billion molecules!
That's because during the past three years, newspapers and magazines around the country published numerous stories overlooking the science involved and discounting the danger of exposure to the most toxic substance in the group: 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), commonly known as dioxin.
In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) induces a reduction in epididymal and ejaculated sperm number in rhesus monkeys.
(TCDD) is a widespread environmental contaminant that produces hepatotoxicity, although the mechanisms are poorly understood.