The mitochondrial uncoupler 2,4-dinitrophenol
attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
DNP - 2,4-dinitrophenol
- is an industrial chemical mainly used as a pesticide.
Many mitochondrial poisons are known complex inhibitors (e.g., rotenone and antimycin A) and uncouplers (e.g., 2,4-dinitrophenol
and carbonyl cyamide 4-(trifluoromethoxy)phenylhydrazone, or FCCP) of oxidative phosphorylation.
In another interesting study, Zhou and colleagues prepared a molecularly imprinted Ti[O.sub.2] photocatalyst having thiol groups for the efficient removal of 2,4-dinitrophenol
from wastewater .
(DNP) pertains to nitroaromatic compounds.
Bennett, "Praziquantel, potassium and 2,4-dinitrophenol
: Analysis of their action on the musculature of Schistosoma mansoni," European Journal of Pharmacology, vol.
Xiao, "Density functional theory study of structural, vibrational, and thermodynamic properties of crystalline 2,4-dinitrophenol
, 2,4-dinitroresorcinol, and 4,6-dinitroresorcinol," Journal of Molecular Structure: THEOCHEM, vol.
We previously reported that activation of endogenous AMPK by 2,4-dinitrophenol
or AICAR significantly decreases the release of MCP-1 from mature 3T3-L1 adipocytes .
Fat-burning substance DNP or 2,4-dinitrophenol
was found in his system.
In situ single pass intestinal perfusion was used to investigate the absorption sites of three constituents in the small intestine, as well as the influence of drug concentrations, concentrations of P-gp inhibitor verapamil hydrochloride, concentrations of MRP2 inhibitor probenecid, and concentrations of energy inhibitor 2,4-dinitrophenol
, in order to discuss the absorption mechanism of the constituents and influent factors (5).
He has called for tighter controls, including licensing of the DNP (2,4-Dinitrophenol
) chemical itself, to make it tougher to get hold of.
In fact, Cl[O.sup.-.sub.4] is a well-known competitive inhibitor of iodide transport as well as N[O.sup.-.sub.3], B[F.sup.-.sub.4], SC[N.sup.-], 2,4-dinitrophenol
, and cardiac glycosides (1,3,24).